ArrayExpress Uploader02067siSRC1 with glucosesiSRC1 with glucosesiSRC1 without glucosesiSRC1 without glucosesictrl with glucosesictrl with glucosesictrl without glucosesictrl without glucosearrayexpress_sid4SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion...24438340E-GEOD-56843/profile/8773/arrayexpressuploader18cancerglucosemitochondrial electron transport chainDec.12, 2014Falsesteroid-receptor-coactivator-1-is-an-integrator-ofE-GEOD-56843_A-AFFY-44Steroid Receptor Coactivator 1 is an Integrator of Glucose and NAD(+)/NADH HomeostasisJul.11, 2014SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion of NADH to NAD(+). NAD(+) and NADH were subsequently identified as metabolites that underlie SRC-1's response to glucose deprivation. Knockdown of SRC-1 in glycolytic cancer cells abrogated their ability to grow in the absence of glucose consistent with SRC-1's role in promoting cellular adaptation to reduced glucose availability RNA profiling was used to examine the effects of SRC-1 perturbation on gene expression in the absence or presence of glucose.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-56843humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-56843/samples/