{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 2067, "factors": [{"GSM1370136": {"TREATMENT": "siSRC1 with glucose"}}, {"GSM1370136": {"TREATMENT": "siSRC1 with glucose"}}, {"GSM1370134": {"TREATMENT": "siSRC1 without glucose"}}, {"GSM1370134": {"TREATMENT": "siSRC1 without glucose"}}, {"GSM1370132": {"TREATMENT": "sictrl with glucose"}}, {"GSM1370132": {"TREATMENT": "sictrl with glucose"}}, {"GSM1370130": {"TREATMENT": "sictrl  without glucose"}}, {"GSM1370129": {"TREATMENT": "sictrl without glucose"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion...", "pubmed_id": 24438340, "geo_gse_id": "E-GEOD-56843", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 8, "tags": ["cancer", "glucose", "mitochondrial electron transport chain"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "steroid-receptor-coactivator-1-is-an-integrator-of", "geo_id_plat": "E-GEOD-56843_A-AFFY-44", "name": "Steroid Receptor Coactivator 1 is an Integrator of Glucose and NAD(+)/NADH Homeostasis", "created": "Jul.11, 2014", "summary": "SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion of NADH to NAD(+). NAD(+) and NADH were subsequently identified as metabolites that underlie SRC-1's response to glucose deprivation. Knockdown of SRC-1 in glycolytic cancer cells abrogated their ability to grow in the absence of glucose consistent with SRC-1's role in promoting cellular adaptation to reduced glucose availability RNA profiling was used to examine the effects of SRC-1 perturbation on gene expression in the absence or presence of glucose.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-56843", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-56843/samples/"}