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Home › Dataset Library › Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

Dataset: Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

We analyzed transcriptional changes in 4 prostate cancer cell lines following treatment with the BET inhibitor I-BET762 using Affymetrix...

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We analyzed transcriptional changes in 4 prostate cancer cell lines following treatment with the BET inhibitor I-BET762 using Affymetrix Human Genome U133 Plus 2.0 Arrays. Four prostate cancer cell lines (NCI-H660, VCaP, LNCaP, PC-3) were treated with DMSO (control) or I-BET762 at 0.5uM or 10uM concentrations for 24 hours. Two biological replicates are included for each treatment group.

Species:
human

Samples:
24

Source:
E-GEOD-56352

PubMed:
24293458

Updated:
Dec.12, 2014

Registered:
Jul.11, 2014


Factors: (via ArrayExpress)
Sample CELL LINE DOSE
GSM1359783 Human cancer cell line, PC3 10uM
GSM1359783 Human cancer cell line, PC3 10uM
GSM135978 Human cancer cell line, PC3 .5uM
GSM135978 Human cancer cell line, PC3 .5uM
GSM1359779 Human cancer cell line, PC3 vehicle
GSM1359779 Human cancer cell line, PC3 vehicle
GSM1359777 Human cancer cell line, LNCAP 10uM
GSM1359777 Human cancer cell line, LNCAP 10uM
GSM1359775 Human cancer cell line, LNCAP .5uM
GSM1359775 Human cancer cell line, LNCAP .5uM
GSM1359773 Human cancer cell line, LNCAP vehicle
GSM1359773 Human cancer cell line, LNCAP vehicle
GSM135977 Human cancer cell line, VCAP 10uM
GSM135977 Human cancer cell line, VCAP 10uM
GSM1359769 Human cancer cell line, VCAP .5uM
GSM1359769 Human cancer cell line, VCAP .5uM
GSM1359767 Human cancer cell line, VCAP vehicle
GSM1359767 Human cancer cell line, VCAP vehicle
GSM1359765 Human cancer cell line, NCIH660 10uM
GSM1359765 Human cancer cell line, NCIH660 10uM
GSM1359763 Human cancer cell line, NCIH660 .5uM
GSM1359763 Human cancer cell line, NCIH660 .5uM
GSM135976 Human cancer cell line, NCIH660 vehicle
GSM135976 Human cancer cell line, NCIH660 vehicle

Tags

  • cancer
  • cell
  • genome
  • prostate
  • prostate cancer

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