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Home › Dataset Library › Effect of co-culture with macrophages on two colon cancer cell lines.

Dataset: Effect of co-culture with macrophages on two colon cancer cell lines.

These data suggest that co-culture with macrophages increases expression of NDRG-1 in epithelial cell lines. The finding is confirmed in...

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These data suggest that co-culture with macrophages increases expression of NDRG-1 in epithelial cell lines. The finding is confirmed in 1 mouse epithelial cell line, and in tissue derived from mice genetically and dietetically altered to increase macrophage infiltration of the small and large intestinal epithelium. NDRG1 is identified as a potential mediator of macrophage effects on tumorigenesis in the large and small intestine. Array data is part of a larger study involving the effects of Vitamin D, in concert with macrophages, on intestinal homeostasis and tumorigenesis, entitled Cell autonomous and non-autonomous interactions of a western-style diet and the vitamin D receptor in intestinal homeostasis and tumorigenesis Cells from human colon cancer cell lines were cultured either alone, with Vitamin D3, with THP1 macrophages, or with THP1 macrophages and Vitamin D3, in a system which allowed no physical contact but exchange of soluble factors between the cell types.

Species:
human

Samples:
10

Source:
E-GEOD-55810

Updated:
Dec.12, 2014

Registered:
Jul.11, 2014


Factors: (via ArrayExpress)
Sample CULTURED WITH CELL TYPE CELL LINE
GSM1346305 VitD3 for 24h macropahges THP1
GSM1346304 none (cultured alone) macropahges THP1
GSM1346303 THP1 macrophages Colorectal carcinoma cells Hke3
GSM1346302 THP1 macrophages and Vitamin D3 Colorectal carcinoma cells Hke3
GSM134630 VitD3 for 24h Colorectal carcinoma cells Hke3
GSM1346300 none (cultured alone) Colorectal carcinoma cells Hke3
GSM1346299 THP1 macrophages Colorectal carcinoma cells HCT116
GSM1346298 THP1 macrophages and Vitamin D3 Colorectal carcinoma cells HCT116
GSM1346297 none (cultured alone) Colorectal carcinoma cells HCT116
GSM1346296 VitD3 for 24h Colorectal carcinoma cells HCT116

Tags

  • cancer
  • cell
  • colon
  • colon cancer
  • epithelial cell
  • intestinal epithelium
  • intestine
  • line
  • macrophage
  • small intestine

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