ArrayExpress Uploaderarrayexpress_sidhuman2 �M Cmp302 for 8 hpBabe-Twist retrovirus2 �M Cmp302 for 4 hpBabe-Twist retrovirusDMSOpBabe-Twist retrovirus2 �M Cmp302 for 8 hpBabe-shGFP retrovirus2 �M Cmp302 for 4 hpBabe-shGFP retrovirusDMSOpBabe-shGFP retrovirus207304Carcinoma cells can acquire key malignant traits by reprogramming their differentiation state via an epithelial-to-mesenchymal transition...24705811E-GEOD-55604/profile/8773/arrayexpressuploader26cancercarcinomaDec.12, 2014FalseE-GEOD-55604_A-AFFY-44a-novel-emt-selective-small-molecule-induces-er-stA novel EMT-selective small molecule induces ER stressJul.11, 2014Carcinoma cells can acquire key malignant traits by reprogramming their differentiation state via an epithelial-to-mesenchymal transition (EMT). Cancer cells that undergo EMT become invasive and resist a wide range of therapies including most chemotherapy drugs and radiation. Such cells are also able to efficiently seed primary and metastatic tumors, making them functionally indistinguishable from tumor-initiating or cancer stem-like cells (TICs or CSCs). Therefore, there is significant interest in finding vulnerabilities of cancer cells that have undergone EMT. A potent EMT-selective small molecule was discovered through a large-scale chemical screen. We used microarray analysis to understand the biological effects of this compound. HMLE_ctrl (human MECs, infected with a pBabe-shGFP retrovirus) and HMLE_Twist (human MECs, infected with a pBabe-Twist retrovirus) cells were treated with solvent control (DMSO), 5 µM or 10 µM of Cmp302 for 6 hours. Microarray analysis was performed to profile global gene expression.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55604http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55604/samples/