{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM1340088": {"TREATMENT": "2 \u00ef\u00bf\u00bdM Cmp302 for 8 h", "INFECTION": "pBabe-Twist retrovirus"}}, {"GSM1340087": {"TREATMENT": "2 \u00ef\u00bf\u00bdM Cmp302 for 4 h", "INFECTION": "pBabe-Twist retrovirus"}}, {"GSM1340086": {"TREATMENT": "DMSO", "INFECTION": "pBabe-Twist retrovirus"}}, {"GSM1340085": {"TREATMENT": "2 \u00ef\u00bf\u00bdM Cmp302 for 8 h", "INFECTION": "pBabe-shGFP retrovirus"}}, {"GSM1340084": {"TREATMENT": "2 \u00ef\u00bf\u00bdM Cmp302 for 4 h", "INFECTION": "pBabe-shGFP retrovirus"}}, {"GSM1340083": {"TREATMENT": "DMSO", "INFECTION": "pBabe-shGFP retrovirus"}}], "id": 2073, "pop_total": 0, "platform": 4, "summary_wrapped": "Carcinoma cells can acquire key malignant traits by reprogramming their differentiation state via an epithelial-to-mesenchymal transition...", "pubmed_id": 24705811, "geo_gse_id": "E-GEOD-55604", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 6, "tags": ["cancer", "carcinoma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-55604_A-AFFY-44", "slug": "a-novel-emt-selective-small-molecule-induces-er-st", "geo_gds_id": "", "name": "A novel EMT-selective small molecule induces ER stress", "created": "Jul.11, 2014", "summary": "Carcinoma cells can acquire key malignant traits by reprogramming their differentiation state via an epithelial-to-mesenchymal transition (EMT). Cancer cells that undergo EMT become invasive and resist a wide range of therapies including most chemotherapy drugs and radiation.  Such cells are also able to efficiently seed primary and metastatic tumors, making them functionally indistinguishable from tumor-initiating or cancer stem-like cells (TICs or CSCs). Therefore, there is significant interest in finding vulnerabilities of cancer cells that have undergone EMT. A potent EMT-selective small molecule was discovered through a large-scale chemical screen. We used microarray analysis to understand the biological effects of this compound. HMLE_ctrl (human MECs, infected with a pBabe-shGFP retrovirus) and HMLE_Twist (human MECs, infected with a pBabe-Twist retrovirus) cells were treated with solvent control (DMSO), 5 \u00b5M or 10 \u00b5M of Cmp302 for 6 hours. Microarray analysis was performed to profile global gene expression.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55604", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55604/samples/"}