{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM1338379": {"TREATMENT": "500 IU/ml recombinant human IFN-gamma"}}, {"GSM1338379": {"TREATMENT": "500 IU/ml recombinant human IFN-gamma"}}, {"GSM1338379": {"TREATMENT": "500 IU/ml recombinant human IFN-gamma"}}, {"GSM1338379": {"TREATMENT": "500 IU/ml recombinant human IFN-gamma"}}, {"GSM1338375": {"TREATMENT": "none"}}, {"GSM1338375": {"TREATMENT": "none"}}, {"GSM1338375": {"TREATMENT": "none"}}, {"GSM1338375": {"TREATMENT": "none"}}], "id": 2107, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "The source of IFN-\u03b3 in ovarian cancer microenvironment and its biological effect to the tumor cells is unclear. The immortalized human...", "geo_gse_id": "E-GEOD-55510", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 8, "tags": ["cancer", "cell", "epithelial cell", "line", "lymphocyte", "ovarian cancer", "surface"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiles-of-ifn-gamma-affected-hos", "geo_id_plat": "E-GEOD-55510_A-AFFY-44", "name": "Gene-expression profiles of IFN-gamma-affected HOSE cells", "created": "Jul.11, 2014", "summary": "The source of IFN-\u03b3 in ovarian cancer microenvironment and its biological effect to the tumor cells is unclear. The immortalized human ovarian surface epithelial cell line, HOSE-E7/hTERT (HOSE) was treated with IFN-\u03b3 and expression microarray analysis was performed, and probes showing significantly higher values in IFN-\u03b3-added group were termed \u201cIFN-\u03b3 signature genes (295 probes)\u201d.  We then applied this signature to our ovarian cancer microarray data, which included 75 ovarian cancer clinical samples, by means of ss-GSEA. IFN-\u03b3 signature score was strongly correlated to the number of infiltrating CD4-positive or CD8-positive lymphocytes in the tumors. These data suggest that the IFN-\u03b3 in the ovarian cancer microenvironment is derived from lymphocytes, and an IFN-\u03b3-rich microenvironment is strongly correlated to a lymphocyte-rich microenvironment. HOSE cells were incubated in 8 separate culture dishes, 4 dishes with and 4 dishes without 500 IU/ml recombinant human IFN-\u03b3 (R&D Systems) in the culture medium for 6 hours prior to the analysis.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55510", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55510/samples/"}