Dataset: Suppression of inflammation in psoriasis blood after IL-17 treatment with ixekizumab

The effect of anti-IL-17 treatment on systemic inflammation is not fully understand. Using cDNA microarray, genomic analysis methods such...

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The effect of anti-IL-17 treatment on systemic inflammation is not fully understand. Using cDNA microarray, genomic analysis methods such as GSEA and ingenuity, we characterized the transcriptional changes in the blood of psoriasis patients afer systemic neutralization of IL-17 compared to baseline (before treatment). We also compared the whole blood-derived transcriptome between psoraisis patients at baseline and healthy volunteers to examine systemic inflammation in psoriasis patients. total RNA was extratced from whole blood from psoriasis patients at baseline and after two weeks of treatment; total RNA was extracted from the whole blood of healthy individuals

Species:: human
Samples:: 81
Source:: E-GEOD-55201
Updated:: Dec.12, 2014
Registered:: Jul.11, 2014

Factors: (via ArrayExpress)

Sample	TIME	SUBJECT ID	SUBJECT CONDITION	SAMPLE GROUP
GSM1331534	week 2, after ixekizumab 150mg subcutaneous treatment	1803	psoriasis patients	Psoriasis treatment
GSM1331533	week 2, after ixekizumab 150mg subcutaneous treatment	1710	psoriasis patients	Psoriasis treatment
GSM1331532	week 2, after ixekizumab 150mg subcutaneous treatment	1615	psoriasis patients	Psoriasis treatment
GSM133153	week 2, after ixekizumab 150mg subcutaneous treatment	1611	psoriasis patients	Psoriasis treatment
GSM1331530	week 2, after ixekizumab 150mg subcutaneous treatment	1209	psoriasis patients	Psoriasis treatment
GSM1331529	week 2, after ixekizumab 150mg subcutaneous treatment	1208	psoriasis patients	Psoriasis treatment
GSM1331528	week 2, after ixekizumab 150mg subcutaneous treatment	1207	psoriasis patients	Psoriasis treatment
GSM1331527	baseline; before treatment	1803	psoriasis patients	Psoriasis Baseline
GSM1331526	baseline; before treatment	1710	psoriasis patients	Psoriasis Baseline
GSM1331525	baseline; before treatment	1615	psoriasis patients	Psoriasis Baseline
GSM1331524	baseline; before treatment	1611	psoriasis patients	Psoriasis Baseline
GSM1331523	baseline; before treatment	1610	psoriasis patients	Psoriasis Baseline
GSM1331522	baseline; before treatment	1209	psoriasis patients	Psoriasis Baseline
GSM133152	baseline; before treatment	1208	psoriasis patients	Psoriasis Baseline
GSM1331520	baseline; before treatment	1207	psoriasis patients	Psoriasis Baseline
GSM1331519	baseline; before treatment	1902	psoriasis patients	Psoriasis Baseline
GSM1331518	baseline; before treatment	1707	psoriasis patients	Psoriasis Baseline
GSM1331517	baseline; before treatment	1706	psoriasis patients	Psoriasis Baseline
GSM1331516	baseline; before treatment	1612	psoriasis patients	Psoriasis Baseline
GSM1331515	baseline; before treatment	1609	psoriasis patients	Psoriasis Baseline
GSM1331514	baseline; before treatment	1608	psoriasis patients	Psoriasis Baseline
GSM1331513	baseline; before treatment	1607	psoriasis patients	Psoriasis Baseline
GSM1331512	baseline; before treatment	1109	psoriasis patients	Psoriasis Baseline
GSM13315	baseline; before treatment	1801	psoriasis patients	Psoriasis Baseline
GSM1331510	baseline; before treatment	1606	psoriasis patients	Psoriasis Baseline
GSM1331509	baseline; before treatment	1505	psoriasis patients	Psoriasis Baseline
GSM1331508	baseline; before treatment	1410	psoriasis patients	Psoriasis Baseline
GSM1331507	baseline; before treatment	1404	psoriasis patients	Psoriasis Baseline
GSM1331506	baseline; before treatment	1403	psoriasis patients	Psoriasis Baseline
GSM1331505	baseline; before treatment	1402	psoriasis patients	Psoriasis Baseline
GSM1331504	baseline; before treatment	1401	psoriasis patients	Psoriasis Baseline
GSM1331503	baseline; before treatment	1605	psoriasis patients	Psoriasis Baseline
GSM1331502	baseline; before treatment	1504	psoriasis patients	Psoriasis Baseline
GSM133150	baseline; before treatment	1502	psoriasis patients	Psoriasis Baseline
GSM1331500	baseline; before treatment	1303	psoriasis patients	Psoriasis Baseline
GSM1331499	baseline; before treatment	1301	psoriasis patients	Psoriasis Baseline
GSM1331498	baseline; before treatment	1104	psoriasis patients	Psoriasis Baseline
GSM1331497	baseline; before treatment	1102	psoriasis patients	Psoriasis Baseline
GSM1331496	baseline; before treatment	1604	psoriasis patients	Psoriasis Baseline
GSM1331495	baseline; before treatment	1603	psoriasis patients	Psoriasis Baseline
GSM1331494	baseline; before treatment	1602	psoriasis patients	Psoriasis Baseline
GSM1331493	baseline; before treatment	1601	psoriasis patients	Psoriasis Baseline
GSM1331492	baseline; before treatment	1205	psoriasis patients	Psoriasis Baseline
GSM133149	baseline; before treatment	1702	psoriasis patients	Psoriasis Baseline
GSM1331490	baseline; before treatment	1614	psoriasis patients	Psoriasis Baseline
GSM1331489	baseline; before treatment	1613	psoriasis patients	Psoriasis Baseline
GSM1331488	baseline; before treatment	1507	psoriasis patients	Psoriasis Baseline
GSM1331487	baseline; before treatment	1503	psoriasis patients	Psoriasis Baseline
GSM1331486	baseline; before treatment	1405	psoriasis patients	Psoriasis Baseline
GSM1331485	baseline; before treatment	1304	psoriasis patients	Psoriasis Baseline
GSM1331484	baseline; before treatment	1108	psoriasis patients	Psoriasis Baseline
GSM1331483	not specified	11855	healthy volunteer	Healthy Control
GSM1331482	not specified	11854	healthy volunteer	Healthy Control
GSM133148	not specified	11853	healthy volunteer	Healthy Control
GSM1331480	not specified	11852	healthy volunteer	Healthy Control
GSM1331479	not specified	11851	healthy volunteer	Healthy Control
GSM1331478	not specified	11850	healthy volunteer	Healthy Control
GSM1331477	not specified	11849	healthy volunteer	Healthy Control
GSM1331476	not specified	11848	healthy volunteer	Healthy Control
GSM1331475	not specified	11847	healthy volunteer	Healthy Control
GSM1331474	not specified	11846	healthy volunteer	Healthy Control
GSM1331473	not specified	11824	healthy volunteer	Healthy Control
GSM1331472	not specified	11823	healthy volunteer	Healthy Control
GSM133147	not specified	11822	healthy volunteer	Healthy Control
GSM1331470	not specified	11821	healthy volunteer	Healthy Control
GSM1331469	not specified	11820	healthy volunteer	Healthy Control
GSM1331468	not specified	11819	healthy volunteer	Healthy Control
GSM1331467	not specified	11818	healthy volunteer	Healthy Control
GSM1331466	not specified	11817	healthy volunteer	Healthy Control
GSM1331465	not specified	11816	healthy volunteer	Healthy Control
GSM1331464	not specified	11815	healthy volunteer	Healthy Control
GSM1331463	not specified	11699	healthy volunteer	Healthy Control
GSM1331462	not specified	11698	healthy volunteer	Healthy Control
GSM133146	not specified	11697	healthy volunteer	Healthy Control
GSM1331460	not specified	11696	healthy volunteer	Healthy Control
GSM1331459	not specified	11695	healthy volunteer	Healthy Control
GSM1331458	not specified	11694	healthy volunteer	Healthy Control
GSM1331457	not specified	11693	healthy volunteer	Healthy Control
GSM1331456	not specified	11692	healthy volunteer	Healthy Control
GSM1331455	not specified	11691	healthy volunteer	Healthy Control
GSM1331454	not specified	11690	healthy volunteer	Healthy Control