Dataset: Suppression of inflammation in psoriasis blood after IL-17 treatment with ixekizumab

The effect of anti-IL-17 treatment on systemic inflammation is not fully understand. Using cDNA microarray, genomic analysis methods such...

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The effect of anti-IL-17 treatment on systemic inflammation is not fully understand. Using cDNA microarray, genomic analysis methods such as GSEA and ingenuity, we characterized the transcriptional changes in the blood of psoriasis patients afer systemic neutralization of IL-17 compared to baseline (before treatment). We also compared the whole blood-derived transcriptome between psoraisis patients at baseline and healthy volunteers to examine systemic inflammation in psoriasis patients. total RNA was extratced from whole blood from psoriasis patients at baseline and after two weeks of treatment; total RNA was extracted from the whole blood of healthy individuals

Species:: human
Samples:: 81
Source:: E-GEOD-55201
Updated:: Dec.12, 2014
Registered:: Jul.11, 2014

Factors: (via ArrayExpress)

Sample	SAMPLE GROUP	SUBJECT ID	SUBJECT CONDITION	TIME
GSM1331534	Psoriasis treatment	1803	psoriasis patients	week 2, after ixekizumab 150mg subcutaneous treatment
GSM1331533	Psoriasis treatment	1710	psoriasis patients	week 2, after ixekizumab 150mg subcutaneous treatment
GSM1331532	Psoriasis treatment	1615	psoriasis patients	week 2, after ixekizumab 150mg subcutaneous treatment
GSM133153	Psoriasis treatment	1611	psoriasis patients	week 2, after ixekizumab 150mg subcutaneous treatment
GSM1331530	Psoriasis treatment	1209	psoriasis patients	week 2, after ixekizumab 150mg subcutaneous treatment
GSM1331529	Psoriasis treatment	1208	psoriasis patients	week 2, after ixekizumab 150mg subcutaneous treatment
GSM1331528	Psoriasis treatment	1207	psoriasis patients	week 2, after ixekizumab 150mg subcutaneous treatment
GSM1331527	Psoriasis Baseline	1803	psoriasis patients	baseline; before treatment
GSM1331526	Psoriasis Baseline	1710	psoriasis patients	baseline; before treatment
GSM1331525	Psoriasis Baseline	1615	psoriasis patients	baseline; before treatment
GSM1331524	Psoriasis Baseline	1611	psoriasis patients	baseline; before treatment
GSM1331523	Psoriasis Baseline	1610	psoriasis patients	baseline; before treatment
GSM1331522	Psoriasis Baseline	1209	psoriasis patients	baseline; before treatment
GSM133152	Psoriasis Baseline	1208	psoriasis patients	baseline; before treatment
GSM1331520	Psoriasis Baseline	1207	psoriasis patients	baseline; before treatment
GSM1331519	Psoriasis Baseline	1902	psoriasis patients	baseline; before treatment
GSM1331518	Psoriasis Baseline	1707	psoriasis patients	baseline; before treatment
GSM1331517	Psoriasis Baseline	1706	psoriasis patients	baseline; before treatment
GSM1331516	Psoriasis Baseline	1612	psoriasis patients	baseline; before treatment
GSM1331515	Psoriasis Baseline	1609	psoriasis patients	baseline; before treatment
GSM1331514	Psoriasis Baseline	1608	psoriasis patients	baseline; before treatment
GSM1331513	Psoriasis Baseline	1607	psoriasis patients	baseline; before treatment
GSM1331512	Psoriasis Baseline	1109	psoriasis patients	baseline; before treatment
GSM13315	Psoriasis Baseline	1801	psoriasis patients	baseline; before treatment
GSM1331510	Psoriasis Baseline	1606	psoriasis patients	baseline; before treatment
GSM1331509	Psoriasis Baseline	1505	psoriasis patients	baseline; before treatment
GSM1331508	Psoriasis Baseline	1410	psoriasis patients	baseline; before treatment
GSM1331507	Psoriasis Baseline	1404	psoriasis patients	baseline; before treatment
GSM1331506	Psoriasis Baseline	1403	psoriasis patients	baseline; before treatment
GSM1331505	Psoriasis Baseline	1402	psoriasis patients	baseline; before treatment
GSM1331504	Psoriasis Baseline	1401	psoriasis patients	baseline; before treatment
GSM1331503	Psoriasis Baseline	1605	psoriasis patients	baseline; before treatment
GSM1331502	Psoriasis Baseline	1504	psoriasis patients	baseline; before treatment
GSM133150	Psoriasis Baseline	1502	psoriasis patients	baseline; before treatment
GSM1331500	Psoriasis Baseline	1303	psoriasis patients	baseline; before treatment
GSM1331499	Psoriasis Baseline	1301	psoriasis patients	baseline; before treatment
GSM1331498	Psoriasis Baseline	1104	psoriasis patients	baseline; before treatment
GSM1331497	Psoriasis Baseline	1102	psoriasis patients	baseline; before treatment
GSM1331496	Psoriasis Baseline	1604	psoriasis patients	baseline; before treatment
GSM1331495	Psoriasis Baseline	1603	psoriasis patients	baseline; before treatment
GSM1331494	Psoriasis Baseline	1602	psoriasis patients	baseline; before treatment
GSM1331493	Psoriasis Baseline	1601	psoriasis patients	baseline; before treatment
GSM1331492	Psoriasis Baseline	1205	psoriasis patients	baseline; before treatment
GSM133149	Psoriasis Baseline	1702	psoriasis patients	baseline; before treatment
GSM1331490	Psoriasis Baseline	1614	psoriasis patients	baseline; before treatment
GSM1331489	Psoriasis Baseline	1613	psoriasis patients	baseline; before treatment
GSM1331488	Psoriasis Baseline	1507	psoriasis patients	baseline; before treatment
GSM1331487	Psoriasis Baseline	1503	psoriasis patients	baseline; before treatment
GSM1331486	Psoriasis Baseline	1405	psoriasis patients	baseline; before treatment
GSM1331485	Psoriasis Baseline	1304	psoriasis patients	baseline; before treatment
GSM1331484	Psoriasis Baseline	1108	psoriasis patients	baseline; before treatment
GSM1331483	Healthy Control	11855	healthy volunteer	not specified
GSM1331482	Healthy Control	11854	healthy volunteer	not specified
GSM133148	Healthy Control	11853	healthy volunteer	not specified
GSM1331480	Healthy Control	11852	healthy volunteer	not specified
GSM1331479	Healthy Control	11851	healthy volunteer	not specified
GSM1331478	Healthy Control	11850	healthy volunteer	not specified
GSM1331477	Healthy Control	11849	healthy volunteer	not specified
GSM1331476	Healthy Control	11848	healthy volunteer	not specified
GSM1331475	Healthy Control	11847	healthy volunteer	not specified
GSM1331474	Healthy Control	11846	healthy volunteer	not specified
GSM1331473	Healthy Control	11824	healthy volunteer	not specified
GSM1331472	Healthy Control	11823	healthy volunteer	not specified
GSM133147	Healthy Control	11822	healthy volunteer	not specified
GSM1331470	Healthy Control	11821	healthy volunteer	not specified
GSM1331469	Healthy Control	11820	healthy volunteer	not specified
GSM1331468	Healthy Control	11819	healthy volunteer	not specified
GSM1331467	Healthy Control	11818	healthy volunteer	not specified
GSM1331466	Healthy Control	11817	healthy volunteer	not specified
GSM1331465	Healthy Control	11816	healthy volunteer	not specified
GSM1331464	Healthy Control	11815	healthy volunteer	not specified
GSM1331463	Healthy Control	11699	healthy volunteer	not specified
GSM1331462	Healthy Control	11698	healthy volunteer	not specified
GSM133146	Healthy Control	11697	healthy volunteer	not specified
GSM1331460	Healthy Control	11696	healthy volunteer	not specified
GSM1331459	Healthy Control	11695	healthy volunteer	not specified
GSM1331458	Healthy Control	11694	healthy volunteer	not specified
GSM1331457	Healthy Control	11693	healthy volunteer	not specified
GSM1331456	Healthy Control	11692	healthy volunteer	not specified
GSM1331455	Healthy Control	11691	healthy volunteer	not specified
GSM1331454	Healthy Control	11690	healthy volunteer	not specified