{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 8751, "factors": [{"GSM1328942": {"GENOTYPE": "wild type; Ptprd+/+p16-/-"}}, {"GSM1328942": {"GENOTYPE": "wild type; Ptprd+/+p16-/-"}}, {"GSM1328944": {"GENOTYPE": "HET; Ptprd+/-p16-/-"}}, {"GSM1328944": {"GENOTYPE": "HET; Ptprd+/-p16-/-"}}, {"GSM1328948": {"GENOTYPE": "KO; Ptprd-/-p16-/-"}}, {"GSM1328948": {"GENOTYPE": "KO; Ptprd-/-p16-/-"}}, {"GSM1328948": {"GENOTYPE": "KO; Ptprd-/-p16-/-"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "PTPRD is a tumor suppressor of glioma that is frequently co-deleted with CDKN2A/p16. We show that Ptprd and p16 cooperate to promote...", "pubmed_id": 24843164, "geo_gse_id": "E-GEOD-55061", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 7, "tags": ["glioma", "nestin"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-rcas-pdgfbnestin-tv-a-glioma", "geo_id_plat": "E-GEOD-55061_A-AFFY-36", "name": "Expression data from RCAS PDGFB/Nestin tv-A glioma cells within Ptprd+/+p16-/- (n=2), Ptprd+/-p16-/- (n=2), and Ptrpd-/-p16-/- (n=3) mice.", "created": "Nov.24, 2014", "summary": "PTPRD is a tumor suppressor of glioma that is frequently co-deleted with CDKN2A/p16. We show that Ptprd and p16 cooperate to promote gliomagenesis in the RCAS PDGFB / Nestin tv-A glioma mouse model. We found unique gene expression changes within tumor cells of Ptprd+/-p16-/- vs. Ptprd+/+p16-/- and Ptprd-/-p16-/- tumor cells. Neonatal mice were injected with RCAS PDGFB GFP. At symptoms, or at 12 weeks post injection, GFP+DAPI- tumor cells were sorted for RNA extraction and hybridization on Affymetrix microarrays.  The mouse strain used was a mixed background of C57/BL6 and FVB/N. Ptprd mice were from Uetani et al. 2000 and p16/Nestin-tvA mice were from Tchouganouva et al. 2007.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55061", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55061/samples/"}