{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1326130": {"GENOTYPE": "Nxnl1-/-", "DOSE": "50 lux"}}, {"GSM132613": {"GENOTYPE": "Nxnl1+/+", "DOSE": "50 lux"}}, {"GSM1326130": {"GENOTYPE": "Nxnl1-/-", "DOSE": "50 lux"}}, {"GSM132613": {"GENOTYPE": "Nxnl1+/+", "DOSE": "50 lux"}}, {"GSM1326130": {"GENOTYPE": "Nxnl1-/-", "DOSE": "50 lux"}}, {"GSM1326135": {"GENOTYPE": "Nxnl1-/-", "DOSE": "5000 lux"}}, {"GSM1326136": {"GENOTYPE": "Nxnl1+/+", "DOSE": "2500 lux"}}, {"GSM1326137": {"GENOTYPE": "Nxnl1+/+", "DOSE": "5000 lux"}}, {"GSM1326136": {"GENOTYPE": "Nxnl1+/+", "DOSE": "2500 lux"}}, {"GSM1326136": {"GENOTYPE": "Nxnl1+/+", "DOSE": "2500 lux"}}, {"GSM1326135": {"GENOTYPE": "Nxnl1-/-", "DOSE": "5000 lux"}}, {"GSM1326137": {"GENOTYPE": "Nxnl1+/+", "DOSE": "5000 lux"}}, {"GSM1326137": {"GENOTYPE": "Nxnl1+/+", "DOSE": "5000 lux"}}, {"GSM1326143": {"GENOTYPE": "Nxnl1-/-", "DOSE": "2500 lux"}}, {"GSM1326143": {"GENOTYPE": "Nxnl1-/-", "DOSE": "2500 lux"}}, {"GSM1326143": {"GENOTYPE": "Nxnl1-/-", "DOSE": "2500 lux"}}], "id": 7565, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Rod-derived Cone Viability Factor is a trophic factor of the thioredoxins family that promotes the survival of cone photoreceptors. It is...", "geo_gse_id": "E-GEOD-54886", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 16, "tags": ["cone", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-54886_A-AFFY-45", "slug": "susceptibility-to-photo-oxidative-damage-of-mice-l", "geo_gds_id": "", "name": "Susceptibility to photo-oxidative damage of mice lacking the Rod derived Cone Viability Factor gene Nxnl1", "created": "Nov.12, 2014", "summary": "Rod-derived Cone Viability Factor is a trophic factor of the thioredoxins family that promotes the survival of cone photoreceptors. It is encoded by the nucleoredoxin-like gene 1 Nxnl1 which also encodes by alternative splicing for RdCVFL, for a thioredoxin enzyme that interacts with the protein TAU. The role of thioredoxins in the defense mechanism against oxidation led us to examine the retinal phenotype of the Nxnl1-/- mouse after photo-oxidative stress. In total 16 samples were analyzed, they represent two different genotypes (wt/wt, ko/ko) both on pure BALB/c background and two doses of light that were tested in triplicate each.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54886", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54886/samples/"}