ArrayExpress Uploader0mouseProbasin-cre; PTENflox/+Probasin-cre; PTENflox/+Probasin-cre; PTENflox/+Probasin-cre; PTENflox/+; SRC-2OE/+Probasin-cre; PTENflox/+; SRC-2OE/+Probasin-cre; PTENflox/+; SRC-2OE/+7561arrayexpress_sid6SRC-2 is frequently amplified or overexpressed in metastatic prostate cancer patients. In this study, we used genetically engineered...E-GEOD-54678/profile/8773/arrayexpressuploader16cancerdorsallateralprostateprostate cancerDec.12, 2014FalseE-GEOD-54678_A-AFFY-45a-pivotal-role-of-src-2-in-metastatic-and-castratiA pivotal role of SRC-2 in Metastatic and Castration Resistant Prostate CancerNov.12, 2014SRC-2 is frequently amplified or overexpressed in metastatic prostate cancer patients. In this study, we used genetically engineered mice, overexpressing SRC-2 specifically in the prostate epithelium as a mouse model to examine the role of SRC-2 in prostate tumorigenesis. Over-expression of SRC-2 in PTEN heterozygous mice accelerates PTEN mutation induced tumor progression and develops a metastasis-prone cancer. We used microarrays to examine the molecular profile of prostate-specific SRC-2 overexpression adult dorsal-lateral prostate in comparison with that of control PTENF/+ heterozygous deletion mice. total RNA was extracted from dorsal-lateral prostate of 7 months old-PTEN flox/+ control and PTEN flox/+; Rosa26-SRC-2 OE/+ adult mice, followed by gene expression profiling using Affymetrix microarrays. Each sample contains pooled prostate RNA from 3 mice.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54678http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54678/samples/