{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1321717": {"GENOTYPE": "Probasin-cre; PTENflox/+"}}, {"GSM1321717": {"GENOTYPE": "Probasin-cre; PTENflox/+"}}, {"GSM1321717": {"GENOTYPE": "Probasin-cre; PTENflox/+"}}, {"GSM1321720": {"GENOTYPE": "Probasin-cre; PTENflox/+; SRC-2OE/+"}}, {"GSM1321720": {"GENOTYPE": "Probasin-cre; PTENflox/+; SRC-2OE/+"}}, {"GSM1321720": {"GENOTYPE": "Probasin-cre; PTENflox/+; SRC-2OE/+"}}], "id": 7561, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "SRC-2 is frequently amplified or overexpressed in metastatic prostate cancer patients. In this study, we used genetically engineered...", "geo_gse_id": "E-GEOD-54678", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["cancer", "dorsal", "lateral", "prostate", "prostate cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-54678_A-AFFY-45", "slug": "a-pivotal-role-of-src-2-in-metastatic-and-castrati", "geo_gds_id": "", "name": "A pivotal role of SRC-2 in Metastatic and Castration Resistant Prostate Cancer", "created": "Nov.12, 2014", "summary": "SRC-2 is frequently amplified or overexpressed in metastatic prostate cancer patients. In this study, we used genetically engineered mice, overexpressing SRC-2 specifically in the prostate epithelium as a mouse model to examine the role of SRC-2 in prostate tumorigenesis. Over-expression of SRC-2 in PTEN heterozygous mice accelerates PTEN mutation induced tumor progression and develops a metastasis-prone cancer. We used microarrays to examine the molecular profile of prostate-specific SRC-2 overexpression adult dorsal-lateral prostate in comparison with that of control PTENF/+ heterozygous deletion  mice. total RNA was extracted from dorsal-lateral prostate of 7 months old-PTEN flox/+ control and PTEN flox/+; Rosa26-SRC-2 OE/+ adult mice, followed by gene expression profiling using Affymetrix microarrays. Each sample contains pooled prostate RNA from 3 mice.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54678", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54678/samples/"}