{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1318788": {"DOSE": "0 mg/kg", "TREATMENT": "Vehicle", "GENOTYPE": "Wildtype"}}, {"GSM1318788": {"DOSE": "0 mg/kg", "TREATMENT": "Vehicle", "GENOTYPE": "Wildtype"}}, {"GSM1318788": {"DOSE": "0 mg/kg", "TREATMENT": "Vehicle", "GENOTYPE": "Wildtype"}}, {"GSM131879": {"DOSE": "150 mg/kg", "TREATMENT": "GW4064", "GENOTYPE": "Wildtype"}}, {"GSM131879": {"DOSE": "150 mg/kg", "TREATMENT": "GW4064", "GENOTYPE": "Wildtype"}}, {"GSM131879": {"DOSE": "150 mg/kg", "TREATMENT": "GW4064", "GENOTYPE": "Wildtype"}}, {"GSM1318794": {"DOSE": "0 mg/kg", "TREATMENT": "Vehicle", "GENOTYPE": "Liver Fxr KO"}}, {"GSM1318794": {"DOSE": "0 mg/kg", "TREATMENT": "Vehicle", "GENOTYPE": "Liver Fxr KO"}}, {"GSM1318794": {"DOSE": "0 mg/kg", "TREATMENT": "Vehicle", "GENOTYPE": "Liver Fxr KO"}}, {"GSM1318797": {"DOSE": "150 mg/kg", "TREATMENT": "GW4064", "GENOTYPE": "Liver Fxr KO"}}, {"GSM1318797": {"DOSE": "150 mg/kg", "TREATMENT": "GW4064", "GENOTYPE": "Liver Fxr KO"}}, {"GSM1318797": {"DOSE": "150 mg/kg", "TREATMENT": "GW4064", "GENOTYPE": "Liver Fxr KO"}}, {"GSM1318800": {"DOSE": "0 mg/kg", "TREATMENT": "Vehicle", "GENOTYPE": "Whole body Fxr KO"}}, {"GSM1318800": {"DOSE": "0 mg/kg", "TREATMENT": "Vehicle", "GENOTYPE": "Whole body Fxr KO"}}, {"GSM1318800": {"DOSE": "0 mg/kg", "TREATMENT": "Vehicle", "GENOTYPE": "Whole body Fxr KO"}}, {"GSM1318803": {"DOSE": "150 mg/kg", "TREATMENT": "GW4064", "GENOTYPE": "Whole body Fxr KO"}}, {"GSM1318803": {"DOSE": "150 mg/kg", "TREATMENT": "GW4064", "GENOTYPE": "Whole body Fxr KO"}}, {"GSM1318803": {"DOSE": "150 mg/kg", "TREATMENT": "GW4064", "GENOTYPE": "Whole body Fxr KO"}}], "id": 8747, "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "Expression profiling of whole body (WB) FXR knockout (KO) mice (FXR WB KO), liver-specific FXR KO mice (AFXR Cre+) and enterocyte...", "geo_gse_id": "E-GEOD-54557", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 18, "tags": ["body", "enterocyte", "liver"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-54557_A-AFFY-36", "slug": "transcription-profiling-of-liver-from-farnesoid-x", "geo_gds_id": "", "name": "Transcription profiling of liver from farnesoid X receptor knockout mice", "created": "Nov.24, 2014", "summary": "Expression profiling of whole body (WB) FXR knockout (KO) mice (FXR WB KO), liver-specific FXR KO mice (AFXR Cre+) and enterocyte specific FXR KO mice (VFXR Cre+) on a C57BL/6J genetic background Whole body (WB) FXR knockout (KO) mice (FXR WB KO), liver-specific FXR KO mice (AFXR Cre+) and enterocyte specific FXR KO mice (VFXR Cre+) on a C57BL/6J genetic background were bred and maintained in the laboratory animal research facility at the University of Kansas Medical Center in rooms under a 12-hour light-dark cycle.  All experiments used 10-16 week-old male mice.  FXR was activated by treatment with the FXR synthetic agonist, GW4064, at 150 mg/kg. GW4064 or vehicle was administered by oral gavage at 6 p.m., followed by a second administration at 8 a.m. the next morning.  Two hours later, the liver was harvested.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54557", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54557/samples/"}