{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1309978": {"GENOTYPE": "Sin3B-deleted"}}, {"GSM1309978": {"GENOTYPE": "Sin3B-deleted"}}, {"GSM1309980": {"GENOTYPE": "wt"}}, {"GSM1309980": {"GENOTYPE": "wt"}}, {"GSM1309982": {"GENOTYPE": "PDEC Sin3B-deleted"}}, {"GSM1309983": {"GENOTYPE": "PDEC wt"}}], "id": 7543, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Pancreatic ductal adenocarcinoma (PDAC) is strikingly resistant to conventional approaches. In this study, we report that the histone...", "geo_gse_id": "E-GEOD-54197", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["adenocarcinoma", "cancer", "ductal adenocarcinoma", "histone", "pancreas", "pancreatic cancer", "pancreatic ductal adenocarcinoma", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-sin3bp-kraspg12d-and-sin3bp-k", "geo_id_plat": "E-GEOD-54197_A-AFFY-45", "name": "Expression data from Sin3Bp+/-KRaspG12D and Sin3Bp-/-KRaspG12D pancreata and from cultured primary pancreatic duct epithelial cells (PDEC) of the same genotype.", "created": "Nov.12, 2014", "summary": "Pancreatic ductal adenocarcinoma (PDAC) is strikingly resistant to conventional approaches. In this study, we report that the histone deacetylase associated SIN3B protein is required for activated KRAS-induced senescence in vivo using a mouse model of pancreatic cancer. We used microarray data to determine if SIN3B regulates KRAS-induced expression of the inflammatory response. Total RNA from Sin3Bp+/-KRaspG12D and Sin3Bp-/-KRaspG12D pancreas (two pancreata for each genotype) or PDEC (one for each genotype) was extracted and hybridized on Affymtrix microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54197", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-54197/samples/"}