ArrayExpress Uploader0human2018arrayexpress_sid4Myocilin, a causative gene for open-angle glaucoma, encodes a secreted glycoprotein of unknown function. To elucidate its function(s), we...24563482E-GEOD-53985/profile/8773/arrayexpressuploader06cellglaucomaglycoproteinlineopen-angle glaucomaDec.12, 2014Falsemyocilin-regulates-cell-proliferation-and-survivalE-GEOD-53985_A-AFFY-44Myocilin regulates cell proliferation and survival by activating the ERK pathwayJul.10, 2014Myocilin, a causative gene for open-angle glaucoma, encodes a secreted glycoprotein of unknown function. To elucidate its function(s), we produced a stably transfected HEK293 cell line expressing myocilin and compared the expression profiles between the myocilin-expressing cell line and a vector control cell line using Affymetrix GeneChip U133 plus 2.0 array. A significant portion of differentially-expressed genes in the myocilin-expressing cells was associated with cell growth and cell death, suggesting that myocilin may have an important role regulating cell growth/survival.. We developed vector control and myocilin-expressing Tet On HEK293 cell lines. The gene expression profiles in two stable cell lines were compared.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53985http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53985/samples/