{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM1305861 1": {}}, {"GSM1305860 1": {}}, {"GSM1305859 1": {}}, {"GSM1305858 1": {}}, {"GSM1305857 1": {}}, {"GSM1305856 1": {}}], "id": 2018, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Myocilin, a causative gene for open-angle glaucoma, encodes a secreted glycoprotein of unknown function. To elucidate its function(s), we...", "pubmed_id": 24563482, "geo_gse_id": "E-GEOD-53985", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 6, "tags": ["cell", "glaucoma", "glycoprotein", "line", "open-angle glaucoma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "myocilin-regulates-cell-proliferation-and-survival", "geo_id_plat": "E-GEOD-53985_A-AFFY-44", "name": "Myocilin regulates cell proliferation and survival by activating the ERK pathway", "created": "Jul.10, 2014", "summary": "Myocilin, a causative gene for open-angle glaucoma, encodes a secreted glycoprotein of unknown function. To elucidate its function(s), we produced a stably transfected HEK293 cell line expressing myocilin and compared the expression profiles between the myocilin-expressing cell line and a vector control cell line using Affymetrix GeneChip U133 plus 2.0 array. A significant portion of differentially-expressed genes in the myocilin-expressing cells was associated with cell growth and cell death, suggesting that myocilin may have an important role regulating cell growth/survival.. We developed vector control and myocilin-expressing Tet On HEK293 cell lines. The gene expression profiles in two stable cell lines were compared.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53985", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53985/samples/"}