ArrayExpress Uploaderarrayexpress_sidhumanK700mg brodalumablesional skinday 15C700mg brodalumablesional skinday 15Fplacebolesional skinday 15I700mg brodalumablesional skinday 15X700mg brodalumablesional skinday 15Z700mg brodalumablesional skinday 15Oplacebolesional skinday 15W700mg brodalumablesional skinday 15J700mg brodalumablesional skinday 15D700mg brodalumablesional skinday 15A140mg brodalumablesional skinday 15R140mg brodalumablesional skinday 15Tplacebolesional skinday 15M350mg brodalumablesional skinday 15U140mg brodalumablesional skinday 15E350mg brodalumablesional skinday 15Splacebolesional skinday 15G140mg brodalumablesional skinday 15H350mg brodalumablesional skinday 15L350mg brodalumablesional skinday 15Q350mg brodalumablesional skinday 15Y350mg brodalumablesional skinday 15P350mg brodalumablesional skinday 15B350mg brodalumablesional skinday 15Vplacebolesional skinday 15K700mg brodalumablesional skinday 43C700mg brodalumablesional skinday 43Fplacebolesional skinday 43I700mg brodalumablesional skinday 43X700mg brodalumablesional skinday 43J700mg brodalumablesional skinday 43W700mg brodalumablesional skinday 43Oplacebolesional skinday 43D700mg brodalumablesional skinday 43Z700mg brodalumablesional skinday 43A140mg brodalumablesional skinday 43R140mg brodalumablesional skinday 43Tplacebolesional skinday 43M350mg brodalumablesional skinday 43U140mg brodalumablesional skinday 43E350mg brodalumablesional skinday 43Splacebolesional skinday 43G140mg brodalumablesional skinday 43H350mg brodalumablesional skinday 43Q350mg brodalumablesional skinday 43L350mg brodalumablesional skinday 8Y350mg brodalumablesional skinday 8P350mg brodalumablesional skinday 8B350mg brodalumablesional skinday 8Vplacebolesional skinday 8Knot specifiedlesional skinpre-doseKnot specifiednon-lesional skinpre-doseCnot specifiedlesional skinpre-doseCnot specifiednon-lesional skinpre-doseFnot specifiedlesional skinpre-doseFnot specifiednon-lesional skinpre-doseInot specifiedlesional skinpre-doseInot specifiednon-lesional skinpre-doseXnot specifiedlesional skinpre-doseXnot specifiednon-lesional skinpre-doseZnot specifiedlesional skinpre-doseZnot specifiednon-lesional skinpre-doseOnot specifiedlesional skinpre-doseOnot specifiednon-lesional skinpre-doseWnot specifiedlesional skinpre-doseWnot specifiednon-lesional skinpre-doseJnot specifiedlesional skinpre-doseJnot specifiednon-lesional skinpre-doseDnot specifiedlesional skinpre-doseDnot specifiednon-lesional skinpre-doseAnot specifiedlesional skinpre-doseAnot specifiednon-lesional skinpre-doseRnot specifiedlesional skinpre-doseRnot specifiednon-lesional skinpre-doseTnot specifiedlesional skinpre-doseMnot specifiedlesional skinpre-doseMnot specifiednon-lesional skinpre-doseUnot specifiedlesional skinpre-doseUnot specifiednon-lesional skinpre-doseEnot specifiedlesional skinpre-doseEnot specifiednon-lesional skinpre-doseSnot specifiedlesional skinpre-doseSnot specifiednon-lesional skinpre-doseGnot specifiedlesional skinpre-doseGnot specifiednon-lesional skinpre-doseHnot specifiedlesional skinpre-doseHnot specifiednon-lesional skinpre-doseLnot specifiedlesional skinpre-doseLnot specifiednon-lesional skinpre-doseQnot specifiedlesional skinpre-doseQnot specifiednon-lesional skinpre-doseYnot specifiedlesional skinpre-doseYnot specifiednon-lesional skinpre-dosePnot specifiedlesional skinpre-dosePnot specifiednon-lesional skinpre-doseBnot specifiedlesional skinpre-doseBnot specifiednon-lesional skinpre-doseVnot specifiedlesional skinpre-doseVnot specifiednon-lesional skinpre-dose472204To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin...E-GEOD-53552/profile/8773/arrayexpressuploader499bodypsoriasisskinDec.12, 2014FalseE-GEOD-53552_A-AFFY-44gene-expression-profiling-in-psoriatic-lesional-3Gene expression profiling in psoriatic lesional and non-lesional skin [brodalumab treatment]Sep.21, 2014To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients. Furthermore, we explored the effects of various doses of brodalumab on lesional skin over time. From each of the 25 psoriasis patients, we obtained two pre-dose biopsies, one from a lesion and the other from non-lesional skin in the same general body geography, and two post-dose biopsies. Total RNA was extracted from 6mm punch biopsies that were split in half. A total of 99 samples were run on Affymetrix HU133 Plus 2.0 microarrays. There was no paired non-lesional sample for 'T_lesional_pre-dose' (skn55789).http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53552http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53552/samples/