{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "id": 4718, "factors": [{"GSM1283115": {"MUTATIONAL STATUS": "PAX8-PPARG", "AGE AT DIAGNOSIS": "64", "ORGANISM PART": "FTC", "SEX": "female"}}, {"GSM1283116": {"MUTATIONAL STATUS": "RAS -", "AGE AT DIAGNOSIS": "57", "ORGANISM PART": "FTC", "SEX": "female"}}, {"GSM1283117": {"MUTATIONAL STATUS": "RAS -", "AGE AT DIAGNOSIS": "77", "ORGANISM PART": "FTC", "SEX": "female"}}, {"GSM1283118": {"MUTATIONAL STATUS": "RAS -", "AGE AT DIAGNOSIS": "38", "ORGANISM PART": "FTC", "SEX": "male"}}, {"GSM1283119": {"MUTATIONAL STATUS": "RAS+", "AGE AT DIAGNOSIS": "48", "ORGANISM PART": "FVPTC", "SEX": "female"}}, {"GSM1283120": {"MUTATIONAL STATUS": "RAS -", "AGE AT DIAGNOSIS": "55", "ORGANISM PART": "FVPTC", "SEX": "female"}}, {"GSM128312": {"MUTATIONAL STATUS": "RAS+", "AGE AT DIAGNOSIS": "58", "ORGANISM PART": "FVPTC", "SEX": "male"}}, {"GSM1283122": {"MUTATIONAL STATUS": "RAS -", "AGE AT DIAGNOSIS": "38", "ORGANISM PART": "FVPTC", "SEX": "male"}}, {"GSM1283123": {"MUTATIONAL STATUS": "RAS+", "AGE AT DIAGNOSIS": "30", "ORGANISM PART": "FVPTC", "SEX": "female"}}, {"GSM1283124": {"MUTATIONAL STATUS": "RAS -", "AGE AT DIAGNOSIS": "11", "ORGANISM PART": "FVPTC", "SEX": "female"}}, {"GSM1283125": {"MUTATIONAL STATUS": "RAS+", "AGE AT DIAGNOSIS": "28", "ORGANISM PART": "FVPTC", "SEX": "male"}}, {"GSM1283126": {"MUTATIONAL STATUS": "PAX8-PPARG", "AGE AT DIAGNOSIS": "72", "ORGANISM PART": "FVPTC", "SEX": "male"}}, {"GSM1283127": {"MUTATIONAL STATUS": "RAS+", "AGE AT DIAGNOSIS": "67", "ORGANISM PART": "PDTC", "SEX": "male"}}, {"GSM1283128": {"MUTATIONAL STATUS": "RAS -", "AGE AT DIAGNOSIS": "38", "ORGANISM PART": "PDTC", "SEX": "female"}}, {"GSM1283129": {"MUTATIONAL STATUS": "RAS+", "AGE AT DIAGNOSIS": "49", "ORGANISM PART": "PDTC", "SEX": "male"}}, {"GSM1283130": {"MUTATIONAL STATUS": "RAS -", "AGE AT DIAGNOSIS": "72", "ORGANISM PART": "PDTC", "SEX": "female"}}, {"GSM128313": {"MUTATIONAL STATUS": "RAS -", "AGE AT DIAGNOSIS": "50", "ORGANISM PART": "PDTC", "SEX": "female"}}, {"GSM1283132": {"MUTATIONAL STATUS": "BRAF -", "AGE AT DIAGNOSIS": "26", "ORGANISM PART": "PTC", "SEX": "female"}}, {"GSM1283133": {"MUTATIONAL STATUS": "BRAF +", "AGE AT DIAGNOSIS": "31", "ORGANISM PART": "PTC", "SEX": "female"}}, {"GSM1283134": {"MUTATIONAL STATUS": "BRAF +", "AGE AT DIAGNOSIS": "38", "ORGANISM PART": "PTC", "SEX": "female"}}, {"GSM1283135": {"MUTATIONAL STATUS": "BRAF +", "AGE AT DIAGNOSIS": "35", "ORGANISM PART": "PTC", "SEX": "female"}}, {"GSM1283136": {"MUTATIONAL STATUS": "BRAF -", "AGE AT DIAGNOSIS": "42", "ORGANISM PART": "PTC", "SEX": "female"}}, {"GSM1283137": {"MUTATIONAL STATUS": "BRAF +", "AGE AT DIAGNOSIS": "64", "ORGANISM PART": "PTC", "SEX": "male"}}, {"GSM1283138": {"MUTATIONAL STATUS": "BRAF -", "AGE AT DIAGNOSIS": "14", "ORGANISM PART": "PTC", "SEX": "female"}}, {"GSM1283139": {"MUTATIONAL STATUS": "n/a", "AGE AT DIAGNOSIS": "46", "ORGANISM PART": "normal thyroid tissue from contralateral lobe of thyroid tumor", "SEX": "female"}}, {"GSM1283140": {"MUTATIONAL STATUS": "n/a", "AGE AT DIAGNOSIS": "38", "ORGANISM PART": "normal thyroid tissue from contralateral lobe of thyroid tumor", "SEX": "female"}}, {"GSM128314": {"MUTATIONAL STATUS": "n/a", "AGE AT DIAGNOSIS": "18-61", "ORGANISM PART": "pool of normal thyroid tissues (commercial source)", "SEX": "Female/Male"}}], "pop_total": 0, "platform": 4, "summary_wrapped": "Poorly differentiated thyroid carcinomas (PDTC) represent a heterogeneous, aggressive entity, presenting features that suggest a...", "pubmed_id": 19809427, "geo_gse_id": "E-GEOD-53157", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 4, "sample_count": 27, "tags": ["genome", "liquid"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiling-associated-with-the-prog", "geo_id_plat": "E-GEOD-53157_A-AFFY-44", "name": "Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas", "created": "Sep.21, 2014", "summary": "Poorly differentiated thyroid carcinomas (PDTC) represent a heterogeneous, aggressive entity, presenting features that suggest a progression from well-differentiated carcinomas. To elucidate the mechanisms underlying such progression and identify novel therapeutical targets, we assessed the genome-wide expression in normal thyroid tissues, well-differentiated thyroid carcinomas and PDTC. RNA were extracted from 2 normal thyroid tissues taken from the opposite lobe of thyroid tumors, and 24 thyroid carcinomas: 5 PDTC, 7 classic papillary thyroid carcinomas (cPTC), 8 follicular variants of PTC (fvPTC) and 4 follicular thyroid carcinomas  (FTC). All samples were obtained at time of surgery and immediately frozen in liquid nitrogen. We also hybridized a commercial pool of human thyroid total RNA (BD Bioscience). PTC were screened for BRAF mutations and rearrangements of RET/PTC and, in addition, follicular variants were also analyzed for RAS mutations and PAX8-PPARG rearrangements. FTC were screened for RAS and PAX8-PPARG rearrangements. PDTC were analyzed for BRAF, RAS and PAX8-PPARG genes.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53157", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53157/samples/"}