ArrayExpress Uploaderarrayexpress_sid4718PAX8-PPARG64FTCfemaleRAS -57FTCfemaleRAS -77FTCfemaleRAS -38FTCmaleRAS+48FVPTCfemaleRAS -55FVPTCfemaleRAS+58FVPTCmaleRAS -38FVPTCmaleRAS+30FVPTCfemaleRAS -11FVPTCfemaleRAS+28FVPTCmalePAX8-PPARG72FVPTCmaleRAS+67PDTCmaleRAS -38PDTCfemaleRAS+49PDTCmaleRAS -72PDTCfemaleRAS -50PDTCfemaleBRAF -26PTCfemaleBRAF +31PTCfemaleBRAF +38PTCfemaleBRAF +35PTCfemaleBRAF -42PTCfemaleBRAF +64PTCmaleBRAF -14PTCfemalen/a46normal thyroid tissue from contralateral lobe of thyroid tumorfemalen/a38normal thyroid tissue from contralateral lobe of thyroid tumorfemalen/a18-61pool of normal thyroid tissues (commercial source)Female/Male04Poorly differentiated thyroid carcinomas (PDTC) represent a heterogeneous, aggressive entity, presenting features that suggest a...19809427E-GEOD-53157/profile/8773/arrayexpressuploader427genomeliquidDec.12, 2014Falsegene-expression-profiling-associated-with-the-progE-GEOD-53157_A-AFFY-44Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomasSep.21, 2014Poorly differentiated thyroid carcinomas (PDTC) represent a heterogeneous, aggressive entity, presenting features that suggest a progression from well-differentiated carcinomas. To elucidate the mechanisms underlying such progression and identify novel therapeutical targets, we assessed the genome-wide expression in normal thyroid tissues, well-differentiated thyroid carcinomas and PDTC. RNA were extracted from 2 normal thyroid tissues taken from the opposite lobe of thyroid tumors, and 24 thyroid carcinomas: 5 PDTC, 7 classic papillary thyroid carcinomas (cPTC), 8 follicular variants of PTC (fvPTC) and 4 follicular thyroid carcinomas (FTC). All samples were obtained at time of surgery and immediately frozen in liquid nitrogen. We also hybridized a commercial pool of human thyroid total RNA (BD Bioscience). PTC were screened for BRAF mutations and rearrangements of RET/PTC and, in addition, follicular variants were also analyzed for RAS mutations and PAX8-PPARG rearrangements. FTC were screened for RAS and PAX8-PPARG rearrangements. PDTC were analyzed for BRAF, RAS and PAX8-PPARG genes.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53157humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53157/samples/