ArrayExpress Uploader09581treatmentAcetamide1300014 daystreatmentAcetamide1300014 daystreatmentAcetamide1300014 daystreatmentcefuroxime225014 daystreatmentcefuroxime225014 daystreatmentcefuroxime225014 daystreatmentC.I Direct Black31467 daystreatmentC.I Direct Black31467 daystreatmentC.I Direct Black31467 dayscontrolCorn Oil4--14 dayscontrolCorn Oil4--14 dayscontrolCorn Oil4--14 dayscontrolCorn Oil3--7 dayscontrolCorn Oil3--7 dayscontrolCorn Oil3--7 daystreatmentCyproterone acetate410014 daystreatmentCyproterone acetate410014 daystreatmentCyproterone acetate410014 daystreatmentdiethylstilbestrol5103 daystreatmentdiethylstilbestrol5103 daystreatmentdiethylstilbestrol5103 daystreatmentdehydroepiandrosterone160014 daystreatmentdehydroepiandrosterone160014 daystreatmentdehydroepiandrosterone160014 daystreatmentDimethylnitrosamine347 daystreatmentDimethylnitrosamine347 daystreatmentDimethylnitrosamine347 daystreatmentEthionine520014 daystreatmentEthionine520014 daystreatmentEthionine520014 daystreatmentMethylcarbamate140014 daystreatmentMethylcarbamate140014 daystreatmentMethylcarbamate140014 dayscontrolmethylcellulose6--14 dayscontrolmethylcellulose6--14 dayscontrolmethylcellulose6--14 dayscontrolmethylcellulose1--14 dayscontrolmethylcellulose1--14 dayscontrolmethylcellulose1--14 dayscontrolmethylcellulose5--14 dayscontrolmethylcellulose5--14 dayscontrolmethylcellulose5--14 dayscontrolmethylcellulose2--14 dayscontrolmethylcellulose2--14 dayscontrolmethylcellulose2--14 daystreatmentMethapyrilene HCl1607 daystreatmentMethapyrilene HCl1607 daystreatmentMethapyrilene HCl1607 daystreatmentnifedipine2314 daystreatmentnifedipine2314 daystreatmentnifedipine2314 daystreatmentPhenobarbital sodium6--14 daystreatmentPhenobarbital sodium6--14 daystreatmentPhenobarbital sodium6--14 daystreatmentpiperonylbutoxide512003 daystreatmentpiperonylbutoxide512003 daystreatmentpiperonylbutoxide512003 daystreatmentThioacetamid119.27 daystreatmentThioacetamid119.27 daystreatmentThioacetamid119.27 daystreatmentWy-146431603 daystreatmentWy-146431603 daystreatmentWy-146431603 daysarrayexpress_sid13In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC),...24830643E-GEOD-53082/profile/8773/arrayexpressuploader563classliverproteinJun.26, 2015Falsecross-platform-toxicogenomics-for-the-prediction-oE-GEOD-53082_A-AFFY-25Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (mRNA)Jan.12, 2015In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular signatures for assessing the potential and mode of compound carcinogenicity, we considered multi-level omics data. Besides evaluating the predictive power of signatures observed on individual biological levels, such as mRNA, miRNA and protein expression, we also introduced novel feature representations which capture putative molecular interactions or pathway alterations by integrating expression profiles across platforms interrogating different biological levels. Male Wistar rats were treated by oral gavage with the eight nongenotoxic hepatocarcinogens Phenobarbital sodium (PB), Piperonylbutoxide (PBO), Dehydroepiandrosterone (DHEA), Acetamide (AA), Methapyrilene HCl (MPy), Methylcarbamate (Mcarb), Diethylstilbestrol (DES) and Ethionine (ETH), the two genotoxic carcinogens C.I Direct Black (CIDB) and dimethylnitrosamine (DMN), the two non-hepatocarcinogens Cefuroxime (CFX) and Nifedipine (Nif), and the three compounds with undefined carcinogenic class Cyproterone acetate (CPA), Thioacetamid (TAA) and Wy-14643 (Wy). Depending on the administered compound, livers were taken after 3, 7, or 14 days for histopathological evaluation. From the five animals per treatment group three animals were selected based on the histopathological findings and subjected to molecular profiling using Affymetrix RG-230A arrays (mRNA expression), Agilent G4473A arrays (miRNA expression) and Zeptosens ZeptoMARK reverse arrays (protein expression).http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53082rathttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-53082/samples/