ArrayExpress Uploader04717ORF1ORF1ORF1EmptyEmptyEmptyarrayexpress_sid4Adenovirus infection leads to increased glycolytic metabolism in host cells. Expression of a single gene product encoded within the E4...24703700E-GEOD-52998/profile/8773/arrayexpressuploader16glucoseDec.12, 2014Falseadenovirus-promotes-host-cell-anabolic-glucose-metE-GEOD-52998_A-AFFY-44Adenovirus promotes host cell anabolic glucose metabolism via MYC activationSep.21, 2014Adenovirus infection leads to increased glycolytic metabolism in host cells. Expression of a single gene product encoded within the E4 early transcription region, E4ORF1, is sufficient to promote increased glycolytic flux in cultured epithelial cells. E4ORF1 reprograms cellular glucose metabolism by augmenting MYC-dependent transcription of metabolic genes. To gain insight into the mechanism by which E4ORF1 promotes increased glycolytic flux, we conducted a global microarray analysis of changes in RNA expression in MCF10A cells induced to accutely express ORF1 versus an empty vector.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-52998humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-52998/samples/