Dataset: Adenovirus promotes host cell anabolic glucose metabolism via MYC activation

Adenovirus infection leads to increased glycolytic metabolism in host cells. Expression of a single gene product encoded within the E4 early transcription region, E4ORF1, is sufficient to promote increased glycolytic flux in cultured epithelial cells. E4ORF1 reprograms cellular glucose metabolism by augmenting MYC-dependent transcription of metabolic genes. To gain insight into the mechanism by which E4ORF1 promotes increased glycolytic flux, we conducted a global microarray analysis of changes in RNA expression in MCF10A cells induced to accutely express ORF1 versus an empty vector.

Species:

human

Samples:

6

Source:

E-GEOD-52998

PubMed:

24703700

Updated:

Dec.12, 2014

Registered:

Sep.21, 2014