ArrayExpress Uploaderarrayexpress_sid7499YOUNGWTYOUNGWTYOUNGWTYOUNGKOYOUNGKOYOUNGKOOLDWTOLDWTOLDWTOLDKOOLDKOOLDKO06Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator...24280126E-GEOD-52550/profile/8773/arrayexpressuploader212gastrocnemiusglucoseglucose intolerancemuscleDec.12, 2014FalseE-GEOD-52550_A-AFFY-45progressive-loss-of-pgc-1alpha-expression-in-agingProgressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammationNov.12, 2014Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. Microarray analysis revealed that a significant proportion of PGC-1alpha-dependent changes in gene expression overlapped with age-associated effects, and aging muscle and muscle lacking PGC-1alpha shared gene signatures of impaired electron transport chain activity and TGFbeta signalling. Gastrocnemius muscle mRNA from young (10 week old) and old (24 month old) wild-type and knock-out (muscle-specific PGC-1alpha, myogenin-cre) C57Bl/6N/6J/129 micehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-52550mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-52550/samples/