{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "id": 7499, "factors": [{"GSM1269619": {"AGE": "YOUNG", "GENOTYPE": "WT"}}, {"GSM1269619": {"AGE": "YOUNG", "GENOTYPE": "WT"}}, {"GSM1269619": {"AGE": "YOUNG", "GENOTYPE": "WT"}}, {"GSM1269622": {"AGE": "YOUNG", "GENOTYPE": "KO"}}, {"GSM1269622": {"AGE": "YOUNG", "GENOTYPE": "KO"}}, {"GSM1269622": {"AGE": "YOUNG", "GENOTYPE": "KO"}}, {"GSM1269625": {"AGE": "OLD", "GENOTYPE": "WT"}}, {"GSM1269625": {"AGE": "OLD", "GENOTYPE": "WT"}}, {"GSM1269625": {"AGE": "OLD", "GENOTYPE": "WT"}}, {"GSM1269628": {"AGE": "OLD", "GENOTYPE": "KO"}}, {"GSM1269628": {"AGE": "OLD", "GENOTYPE": "KO"}}, {"GSM1269628": {"AGE": "OLD", "GENOTYPE": "KO"}}], "pop_total": 0, "platform": 6, "summary_wrapped": "Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator...", "pubmed_id": 24280126, "geo_gse_id": "E-GEOD-52550", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 12, "tags": ["gastrocnemius", "glucose", "glucose intolerance", "muscle"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-52550_A-AFFY-45", "slug": "progressive-loss-of-pgc-1alpha-expression-in-aging", "geo_gds_id": "", "name": "Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation", "created": "Nov.12, 2014", "summary": "Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. Microarray analysis revealed that a significant proportion of PGC-1alpha-dependent changes in gene expression overlapped with age-associated effects, and aging muscle and muscle lacking PGC-1alpha shared gene signatures of impaired electron transport chain activity and TGFbeta signalling. Gastrocnemius muscle mRNA from young (10 week old) and old (24 month old) wild-type and knock-out (muscle-specific PGC-1alpha, myogenin-cre) C57Bl/6N/6J/129 mice", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-52550", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-52550/samples/"}