Dataset: Transcriptional responses of mantle cell lymphoma (MCL) after NIK knockdown
MCL lines were treated with or without 100ng/ml doxycycline for 7 days This experiment is designed to see if shRNA-mediated knockdown of...
MCL lines were treated with or without 100ng/ml doxycycline for 7 days This experiment is designed to see if shRNA-mediated knockdown of NIK downregulates NFKB signaling in MCL lines with mutations in upstream regulators of the alternative pathway (TRAF2 & TRAF3) MCL cells carrying inducible non-targeting control (NTC) shRNA, NIKshRNA#1 (NIKsh#1), or NIKshRNA#2 (NIKsh#2) were seeded in 6well dishes and treated for 7 days with or without 100ng/ml doxycycline.
- Species:
- human
- Samples:
- 12
- Source:
- E-GEOD-52435
- Updated:
- Dec.12, 2014
- Registered:
- Jul.11, 2014
Factors:
(via ArrayExpress)
| Sample | NIK PATHWAY MUTATION | CELL LINE | TREATMENT | KNOCKDOWN |
|---|---|---|---|---|
| GSM1266798 | TRAF3 deletion | Maver-1 | 100ng/ml DOX | NIK |
| GSM1266797 | TRAF3 deletion | Maver-1 | 0ng/ml DOX | NIK |
| GSM1266798 | TRAF3 deletion | Maver-1 | 100ng/ml DOX | NIK |
| GSM1266797 | TRAF3 deletion | Maver-1 | 0ng/ml DOX | NIK |
| GSM1266794 | TRAF3 deletion | Maver-1 | 100ng/ml DOX | control |
| GSM1266793 | TRAF3 deletion | Maver-1 | 0ng/ml DOX | control |
| GSM1266792 | TRAF2 nonsense | Z-138 | 100ng/ml DOX | NIK |
| GSM126679 | TRAF2 nonsense | Z-138 | 0ng/ml DOX | NIK |
| GSM1266792 | TRAF2 nonsense | Z-138 | 100ng/ml DOX | NIK |
| GSM126679 | TRAF2 nonsense | Z-138 | 0ng/ml DOX | NIK |
| GSM1266788 | TRAF2 nonsense | Z-138 | 100ng/ml DOX | control |
| GSM1266787 | TRAF2 nonsense | Z-138 | 0ng/ml DOX | control |