ArrayExpress Uploader0human25periplaque region from MS spinal cord46female25normal appearing white matter from MS spinal cord46female26periplaque region from MS spinal cord61male26normal appearing white matter from MS spinal cord61male24periplaque region from MS spinal cord52female24normal appearing white matter from MS spinal cord52female28periplaque region from MS spinal cord54female28normal appearing white matter from MS spinal cord54female22periplaque region from MS spinal cord39female22normal appearing white matter from MS spinal cord39female20periplaque region from MS spinal cord46male20normal appearing white matter from MS spinal cord46male36periplaque region from MS spinal cord52female36normal appearing white matter from MS spinal cord52female19periplaque region from MS spinal cord62female19normal appearing white matter from MS spinal cord62female4706arrayexpress_sid4There have been few studies that have focused on the periplaque regions surrounding demyelinated plaques, especially in spinal cords....E-GEOD-52139/profile/8773/arrayexpressuploader416multiple sclerosissecondary progressive multiple sclerosisspinal cordDec.12, 2014Falseexpression-data-from-periplaque-regions-in-multiplE-GEOD-52139_A-AFFY-44Expression data from periplaque regions in multiple sclerosis spinal cordSep.21, 2014There have been few studies that have focused on the periplaque regions surrounding demyelinated plaques, especially in spinal cords. Areas of incomplete demyelination have been demonstrated but poorly studied. The present study aimed to analyze the molecular immunopathology of periplaque demyelinated lesions (PDLs) in the spinal cord of patients with secondary progressive multiple sclerosis (MS). To achieve this goal, the transcriptomic profiles of PDLs were analyzed in post-mortem tissues derived from the cervical spinal cord of 8 patients with primary or secondary progressive MS. Sixteen spinal cord samples were microdissected for RNA extraction and hybridization on Affymetrix microarrays. Eight periplaque samples (P) were compared to normal appearing white matter (N) from the same patient.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-52139http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-52139/samples/