Dataset: Anticancer properties of distinct antimalaria drug classes

Background: Antimalarials have anticancer potential. Results: We have systematically tested five distinct antimalaria drugs in a panel...

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Background: Antimalarials have anticancer potential. Results: We have systematically tested five distinct antimalaria drugs in a panel of cancer cell lines. Conclusion: Three antimalarial classes display potent antiproliferative activity, and their potency is correlated with cancer cell gene expression patterns. Significance: We confirm and extend anticancer potential of these antimalarials and we discuss their therapeutic potential based on clinical data. Key words: Malaria, Anticancer drug, Drug Discovery, Genomics, Gene Expression, Bioinformatics, Cancer Affymetrix® HG-U133 Plus 2.0 mRNA expression arrays were used to determine the expression. CEL result files were pre-processed using the RMA (Irizarry et al, 2003) algorithm. This microarray analysis was performed for 91 cell lines.

Species:: human
Samples:: 91
Source:: E-GEOD-51739
Updated:: Dec.12, 2014
Registered:: Jul.11, 2014

Factors: (via ArrayExpress)

Sample	DIFFERENTIATION	ORIGIN	AGE	CELL LINE	SEX
GSM1251860	not known	primary	72	1752	male
GSM1251859	poor	primary	56	269	male
GSM1251858	not known	not known	32	KCL-22	female
GSM1251857	poor	not known	Not available	PC-3M	male
GSM1251856	poor	not known	11	Raji	male
GSM1251855	not known	not known	62	NCI-H929	female
GSM1251854	not known	primary	51	486	female
GSM1251853	not known	metastasis	22	276	male
GSM1251852	not known	primary	55	698	male
GSM125185	not known	not known	59	KG-1	male
GSM1251850	poor	primary	60	251	male
GSM1251849	moderate	primary	70	94	male
GSM1251848	not known	not known	73	JURL-MK1	male
GSM1251847	good	metastasis	70	546	male
GSM1251846	poor	metastasis	63	289	male
GSM1251845	poor	metastasis	58	526	male
GSM1251844	poor	not known	Not available	NCI-H460	male
GSM1251843	poor	primary	19	MOLT-4	male
GSM1251842	not known	not known	11	Saos-2	female
GSM125184	poor	primary	56	1121	female
GSM1251840	poor	recurrent	43	1781	male
GSM1251839	not known	metastasis	41	520	male
GSM1251838	not known	metastasis	35	1341	female
GSM1251837	not known	not known	60	NIH:OVCAR-3	female
GSM1251836	not known	primary	74	1183	male
GSM1251835	poor	not known	53	K-562	female
GSM1251834	poor	not known	69	MCF-7	female
GSM1251833	not known	not known	81	T-24	female
GSM1251832	poor	not known	Not available	IM-9	female
GSM125183	not known	metastasis	63	462	male
GSM1251830	not known	not known	24	PL-21	male
GSM1251829	poor	not known	Not available	RKO	Not available
GSM1251828	good	metastasis	51	401	female
GSM1251827	poor	not known	Not available	HCT-116	male
GSM1251826	poor	not known	51	MDA-MB-231	female
GSM1251825	poor	not known	14	Jurkat	male
GSM1251824	good	primary	76	899	female
GSM1251823	not known	not known	56	lp-1	female
GSM1251822	poor	not known	36	HL-60	female
GSM125182	poor	not known	44	HT-29	female
GSM1251820	moderate	metastasis	60	1657	female
GSM1251819	good	primary	66	575	male
GSM1251818	not known	primary	55	MEG-01	male
GSM1251817	poor	not known	Not available	22Rv1	male
GSM1251816	poor	not known	69	DU-145	male
GSM1251815	not known	not known	56	CAL-27	male
GSM1251814	poor	not known	37	U-937	male
GSM1251813	not known	not known	7	TE671	female
GSM1251812	not known	primary	5	EM-2	female
GSM12518	poor	metastasis	66	1138	female
GSM1251810	poor	metastasis	52	1352	male
GSM1251809	poor	recurrent	73	1118	female
GSM1251808	poor	metastasis	Not available	1218	female
GSM1251807	not known	not known	31	NOMO-1	female
GSM1251806	good	not known	53	HUT-78	male
GSM1251805	not known	not known	56	PANC-1	male
GSM1251804	not known	not known	10	MV4-11	male
GSM1251803	poor	metastasis	55	1103	male
GSM1251802	not known	metastasis	60	1792	male
GSM125180	poor	not known	61	RPMI8226	male
GSM1251800	not known	not known	65	OCI-AML2	male
GSM1251799	poor	not known	50	LNCAP	male
GSM1251798	poor	primary	59	629	male
GSM1251797	poor	not known	36	L-363	female
GSM1251796	poor	primary	54	393	male
GSM1251795	poor	primary	63	3011	male
GSM1251794	good	metastasis	46	DiFi	female
GSM1251793	poor	primary	34	529	female
GSM1251792	poor	metastasis	59	983	male
GSM125179	undifferentiated	not known	57	JHH-6	female
GSM1251790	not known	not known	51	JHH-4	male
GSM1251789	not known	not known	57	JHH-2	male
GSM1251788	poor	not known	38	OCUM-1	female
GSM1251787	poor	metastasis	35	NUGC-4	female
GSM1251786	poor	not known	62	MKN45	female
GSM1251785	moderate	not known	63	IM95	male
GSM1251784	poor	not known	66	Fu97	female
GSM1251783	not known	not known	54	SNU-878	female
GSM1251782	not known	not known	49	SNU-761	male
GSM125178	not known	not known	52	SNU-739	male
GSM1251780	not known	not known	43	SNU-475	male
GSM1251779	not known	not known	52	SNU-449	male
GSM1251778	not known	not known	40	SNU-423	male
GSM1251777	undifferentiated	not known	68	HLE	male
GSM1251776	not known	not known	4	CCRF-CEM-VCR	female
GSM1251775	not known	not known	Not available	SNU-899	Not available
GSM1251774	not known	not known	Not available	SNU-1076	Not available
GSM1251773	poor	not known	62	498	male
GSM1251772	poor	not known	4	CCRF-CEM	female
GSM125177	not known	not known	72	MKN1	male
GSM1251770	good	not known	39	MKN7	male