BioGPS
  • Home
  • Help
  • Plugins
  • Datasets
  • Sign Up
  • Login
Examples: Gene Symbol(s), Gene Ontology, Splicing plugins, Melanoma datasets
advanced
Home › Dataset Library › Expression data from Gdap1 knock-out (deletion of exon 5) mice

Dataset: Expression data from Gdap1 knock-out (deletion of exon 5) mice

GDAP1 is a mitochondrial fission factor and mutations in GDAP1 cause Charcot-Marie-Tooth disease. Gdap1 knockout mice, mimicking genetic...

Registered by ArrayExpress Uploader
View Dataset

GDAP1 is a mitochondrial fission factor and mutations in GDAP1 cause Charcot-Marie-Tooth disease. Gdap1 knockout mice, mimicking genetic alterations of patients suffering from severe CMT forms, develop an age-related, hypomyelinating peripheral neuropathy. We used microarrays to determine changes in the expression profiles in the peripheral nervous system before a phenotype was detectable in the animal model (2 month of age). To seek changes in gene expression patterns of Gdap1-/- mice, we isolated motoneurons by laser dissection and took sciatic nerve lysates of two-month-old mice and purified RNA of five mice. Based on the amount and quality of the isolated RNA we selected three samples per tissue (sciatic nerve lysate and motoneruons) and genotype (GDAP1-/- or wild type). Note: the probe sets for Gdap1 lie within exon 4 and exon 6, thus no apparent loss of Gdap1 mRNA expression is present in Gdap1-/- animals.

Species:
mouse

Samples:
12

Source:
E-GEOD-51650

Updated:
Dec.12, 2014

Registered:
Nov.12, 2014


Factors: (via ArrayExpress)
Sample GENOTYPE
GSM1250123 wild type
GSM1250123 wild type
GSM1250123 wild type
GSM1250126 Gdap1 knock-out
GSM1250126 Gdap1 knock-out
GSM1250126 Gdap1 knock-out
GSM1250123 wild type
GSM1250123 wild type
GSM1250123 wild type
GSM1250126 Gdap1 knock-out
GSM1250126 Gdap1 knock-out
GSM1250126 Gdap1 knock-out

Tags

  • charcot-marie-tooth disease
  • disease
  • exon
  • nerve
  • nervous system
  • neuropathy
  • peripheral
  • peripheral nervous system
  • peripheral neuropathy
  • sciatic nerve
  • tooth
  • tooth disease

Other Formats

JSON    XML
  • About
  • Blog
  • Help
  • FAQ
  • Downloads
  • API
  • iPhone App
  • Email updates
© 2022 The Scripps Research Institute. All rights reserved. (ver 94eefe6 )
  • Terms of Use