{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1249855": {"GENOTYPE": "Ikk\u03b1AA/AA"}}, {"GSM1249855": {"GENOTYPE": "Ikk\u03b1AA/AA"}}, {"GSM1249857": {"GENOTYPE": "\u03b2-catc.a."}}, {"GSM1249857": {"GENOTYPE": "\u03b2-catc.a."}}, {"GSM1249859": {"GENOTYPE": "\u03b2-catc.a./Ikk\u03b1AA/AA"}}, {"GSM1249859": {"GENOTYPE": "\u03b2-catc.a./Ikk\u03b1AA/AA"}}, {"GSM124986": {"GENOTYPE": "wild type"}}, {"GSM124986": {"GENOTYPE": "wild type"}}], "id": 8733, "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "Depending on the tumor type I\u03baB kinase \u03b1 (IKK\u03b1) can act as tumor promoter or tumor suppressor in various malignancies. Here we...", "geo_gse_id": "E-GEOD-51631", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 8, "tags": ["cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "ikk-promotes-intestinal-tumorigenesis", "geo_id_plat": "E-GEOD-51631_A-AFFY-36", "name": "IKK\u03b1 promotes intestinal tumorigenesis", "created": "Nov.24, 2014", "summary": "Depending on the tumor type I\u03baB kinase \u03b1 (IKK\u03b1) can act as tumor promoter or tumor suppressor in various malignancies. Here we demonstrate a key function of IKK\u03b1 in the suppression of a tumoricidal microenvironment during intestinal carcinogenesis. Mice deficient in IKK\u03b1 kinase activity are largely protected from intestinal tumor development that is dependent on the enhanced recruitment of IFN\u03b3 expressing M1-like myeloid cells. In IKK\u03b1 mutant mice M1-like polarization is not controlled in a cell autonomous manner but depends rather on the interplay of both IKK\u03b1 mutant tumor epithelia and immune cells. Tamoxifen-inducible \u03b2-catc.a. mice comprise an excellent model to study Wnt-dependent tumor initiation. These mice are characterized by IEC-restricted stabilization of \u03b2-catenin causing rapid expansion of intestinal crypts and loss of differentiated IEC. To further explore the underlying IKK\u03b1 controlled pro-proliferative mechanism, we performed a microarray analysis comparing RNA isolated from wildtype, Ikk\u03b1AA/AA, \u03b2-catc.a. or \u03b2-catc.a./Ikk\u03b1AA/AA IEC 15 days after the first tamoxifen administration. and within 4 weeks \u03b2-catc.a. mice succumb to this marked crypt hyperproliferation", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-51631", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-51631/samples/"}