ArrayExpress Uploader07459creatine-supplemented dietcreatine-supplemented dietcreatine-supplemented dietcreatine-supplemented dietcreatine-supplemented dietcreatine-supplemented dietcontrolcontrolcontrolcontrolcontrolcontrolcontrolarrayexpress_sid6Here we show that oral creatine (Cr) supplementation leads to increased life span in mice. Treated mice showed improved neurobehavioral...17416441E-GEOD-5140/profile/8773/arrayexpressuploader113brainlipofuscinDec.12, 2014Falsetranscription-profiling-of-brains-from-mice-fed-wiE-GEOD-5140_A-AFFY-45Transcription profiling of brains from mice fed with or without creatine supplementation to study the molecular mechanism of creatine improving health and life span in miceNov.12, 2014Here we show that oral creatine (Cr) supplementation leads to increased life span in mice. Treated mice showed improved neurobehavioral performance, decreased accumulation of the aging pigment lipofuscin and upregulation of anti-aging genes in brain. As Cr is virtually free of adverse effects, it may be a promising food supplement for healthy aging in man. Experiment Overall Design: 6 biological replicates for creatine-treated mice, 7 biological replicates for untreated mice.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-5140mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-5140/samples/