BioGPS
  • Home
  • Help
  • Plugins
  • Datasets
  • Sign Up
  • Login
Examples: Gene Symbol(s), Gene Ontology, Splicing plugins, Melanoma datasets
advanced
Home › Dataset Library › Expression data from adult Shh-responding astroglia cells in mice

Dataset: Expression data from adult Shh-responding astroglia cells in mice

Sonic hedgehog (Shh) signals via Gli transcription factors to promote maintenance and proliferation of neural stem cells in the adult...

Registered by ArrayExpress Uploader
View Dataset

Sonic hedgehog (Shh) signals via Gli transcription factors to promote maintenance and proliferation of neural stem cells in the adult mouse forebrain. We have analyzed the gene expression pattern in neurogenic Shh-responding astroglia (= neural stem cells ) in the subventicular zone of the lateral ventricle and dentate gyrus of the hippocampus in comparison to the non-neurogenic Shh-responding glia (=Bergman glia) in the cerebellum to identify the genes specifically involved in neurogenic function downstream of Shh signaling. In this dataset, we include the expression data obtained from FACS-sorted Gli1+ GFAP+ cells from microdissected SVZ, hippocampus and cerebellum. GFAP expression is based on hGFAP-GFP reporter line and Gli1 expression is lineage marked using Gli1-CreER;ROSA26-tdTomato mice. 15 Total samples were analyzed. We compared expression levels of SVZ vs. Cerebellum, Hippocampus vs. Cerebelllum to identify genes which had more than 4 fold change in expression levels with p < 0.01. From this narrowed list, we compared between SVZ and Hippocampus to identify the common genes up and down regulated. In addition, we also identified commonly expressed genes in hippocampus and SVZ at high level.

Species:
mouse

Samples:
15

Source:
E-GEOD-50950

Updated:
Dec.12, 2014

Registered:
Nov.12, 2014


Factors: (via ArrayExpress)
Sample ORGANISM PART
GSM1233154 FACS-isolated cells from SVZ
GSM1233154 FACS-isolated cells from SVZ
GSM1233154 FACS-isolated cells from SVZ
GSM1233154 FACS-isolated cells from SVZ
GSM1233154 FACS-isolated cells from SVZ
GSM1233159 FACS-isolated cells from hippocampus
GSM1233159 FACS-isolated cells from hippocampus
GSM1233159 FACS-isolated cells from hippocampus
GSM1233159 FACS-isolated cells from hippocampus
GSM1233159 FACS-isolated cells from hippocampus
GSM1233164 FACS-isolated cells from cerebellum
GSM1233164 FACS-isolated cells from cerebellum
GSM1233164 FACS-isolated cells from cerebellum
GSM1233164 FACS-isolated cells from cerebellum
GSM1233164 FACS-isolated cells from cerebellum

Tags

  • cerebellum
  • forebrain
  • hippocampus
  • lateral
  • lateral ventricle
  • line
  • ventricle

Other Formats

JSON    XML
  • About
  • Blog
  • Help
  • FAQ
  • Downloads
  • API
  • iPhone App
  • Email updates
© 2023 The Scripps Research Institute. All rights reserved. (ver 94eefe6 )
  • Terms of Use