4ArrayExpress Uploader0human8470uninvolveduninvolved skin biopsy8470lesionallesional skin biopsy7912uninvolveduninvolved skin biopsy7912lesionallesional skin biopsy7450lesionallesional skin biopsy7450uninvolveduninvolved skin biopsy6690uninvolveduninvolved skin biopsy6690lesionallesional skin biopsy2192arrayexpress_sidhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-50790Psoriasis is a chronic inflammatory skin disease characterized by marked proliferation of keratinocytes leading to pronounced epidermal.../profile/8773/arrayexpressuploader38diseasegenomepsoriasisskinskin diseasetrunkDec.12, 2014FalseE-GEOD-50790_A-AFFY-44gene-expression-in-psoriasis-lesions-and-uninvolveGene expression in psoriasis lesions and uninvolved skinJul.11, 2014Psoriasis is a chronic inflammatory skin disease characterized by marked proliferation of keratinocytes leading to pronounced epidermal hyperplasia, elongation of rete ridges and hyperkeratosis. The most common form of psoriasis, chronic plaque psoriasis (Psoriasis vulgaris), involves relatively stable occurrence and progression of sharply demarcated lesions, usually on the trunk and extremities, which share a combination of trademark histological features, including tortuous and dilated dermal capillaries, loss of the epidermal granular layer, and accumulation of neutrophils beneath parakeratotic scale. In this study, whole-genome transcriptional profiling was used to characterize gene expression in 4 lesional and uninvolved skin samples obtained from patients with stable chronic plaque psoriasis.Skin mRNA expression was analysed by microarray. Four individuals with chronic plaque psoriasis were enrolled. 6 mm punch biopsies were obtained under local anaesthesia (lidocaine) from uninvolved skin and a target plaque.E-GEOD-50790http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-50790/samples/