{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM1224518": {"COMPOUND": "control"}}, {"GSM1224518": {"COMPOUND": "control"}}, {"GSM1224518": {"COMPOUND": "control"}}, {"GSM1224518": {"COMPOUND": "control"}}, {"GSM1224518": {"COMPOUND": "control"}}, {"GSM1224518": {"COMPOUND": "control"}}, {"GSM1224524": {"COMPOUND": "L-proline"}}, {"GSM1224524": {"COMPOUND": "L-proline"}}, {"GSM1224524": {"COMPOUND": "L-proline"}}, {"GSM1224524": {"COMPOUND": "L-proline"}}, {"GSM1224524": {"COMPOUND": "L-proline"}}, {"GSM1224524": {"COMPOUND": "L-proline"}}], "id": 7423, "pop_total": 0, "platform": 6, "summary_wrapped": "We found that the non-essential amino acid L-Proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem...", "geo_gse_id": "E-GEOD-50603", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 12, "tags": ["amino acid", "cell", "embryonic stem cell", "genome", "proline", "spindle", "stem cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "effect-of-l-proline-on-mouse-embryonic-stem-cells", "geo_id_plat": "E-GEOD-50603_A-AFFY-45", "name": "Effect of L-Proline on mouse embryonic stem cells (ESCs)", "created": "Nov.12, 2014", "summary": "We found that the non-essential amino acid L-Proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells (ESCs) into mesenchymal-like, spindle-shaped, highly motile, invasive pluripotent stem cells. This embryonic stem cell-to-mesenchymal-like transition (esMT) is accompanied by a genome-wide remodeling of the transcriptome We used microarrays to elucidate whether a diverse transcriptional program is the basis of the morphological and motility differences between ESCs and L- Proline treated ESCs (PiCs) Total RNA was extracted from Control (ESCs) and L-Proline treated mouse embryonic stem cells (PiCs) and hybridized on Affimetrix microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-50603", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-50603/samples/"}