ArrayExpress Uploader0humanTh1Th17 cells580Th1 cells580Th1Th17 cells674Th1 cells674Th1Th17 cells676Th1 cells676Th1Th17 cells661Th1 cells6612311arrayexpress_sid4We previously demonstrated that Th1Th17 cells are highly permissive to HIV-1, whereas Th1 cells are relatively resistant. Here, we...E-GEOD-50175/profile/8773/arrayexpressuploader28genomesuperiorDec.12, 2014Falseexpression-data-from-human-th1-and-th1th17-cellsE-GEOD-50175_A-AFFY-44Expression data from human Th1 and Th1Th17 cellsJul.12, 2014We previously demonstrated that Th1Th17 cells are highly permissive to HIV-1, whereas Th1 cells are relatively resistant. Here, we investigated molecular mechanisms underlying these differences. Superior HIV replication in Th1Th17 vs. Th1 cells was regulated by entry and post-entry mechanisms. We used microarrays to detail the gene expression signatures caracterizing Th1 cells from Th1Th17. Primary human Th1 (CXCR3+CCR6- phenotype) and Th1Th17 (CXCR3+CCR6- phenotype) CD4+ T-cells were isolated by flow cytometry from HIV-uninfected, healthy donors. Cells were stimulated via CD3/CD28 for 3 days. The RNA was extracted and hybridized on the GeneChip® Human Genome U133 Plus 2.0 Array (Affymetrix).http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-50175http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-50175/samples/