Dataset: Validation of a histology-independent prognostic gene signature for early stage, non-small cell lung cancer including stage IA patients

Background: Patients with early stage non-small cell lung carcinoma (NSCLC) may benefit from treatments based on more accurate prognosis....

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Background: Patients with early stage non-small cell lung carcinoma (NSCLC) may benefit from treatments based on more accurate prognosis. A 15-gene prognostic classifier for NSCLC was identified from mRNA expression profiling of tumor samples from the NCIC CTG JBR.10 trial. Here, we assessed its value in an independent set of cases. Methods: Expression profiling was performed on RNA from frozen, resected tumor tissues corresponding to 181 Stage I and II NSCLC cases collected at University Health Network (UHN181). Kaplan-Meier methodology was used to estimate three year overall survival probabilities and the prognostic effect of the classifier was assessed using log-rank testing. Cox proportional hazards model evaluated the signature's effect adjusting for clinical prognostic factors. Results: Expression data of the 15-gene classifier stratified UHN181 cases into high and low-risk subgroups with significantly different overall survival (HR=1.92, 95% CI: 1.15-3.23, p=0.012). Its strength as a prognostic classifier was superior to stage alone (HR=1.52, 95% CI: 0.90-2.55, p-value=0.11). In subgroup analysis, this classifier predicted survival in 127 Stage I patients (HR=2.17, 95% CI: 1.12-4.20, p=0.018) and the smaller subgroup of 48 Stage IA patients (HR=5.61, 95% CI: 1.19-26.45, p=0.014. The signature was prognostic for both adenocarcinoma and squamous cell carcinoma cases (HR= 1.76, p-value=0.058; HR= 4.19, p-value=0.045, respectively). Conclusions: The prognostic accuracy of a 15-gene classifier was validated in an independent cohort of 181 early stage NSCLC samples including Stage IA cases and in different NSCLC histologic subtypes. Expression profiling was performed on RNA from frozen, resected tumor tissues corresponding to 181 Stage I and II NSCLC cases collected at University Health Network (UHN181). !Series_contributor = Sandy,D,Der

Species:: human
Samples:: 181
Source:: E-GEOD-50081
PubMed:: 24305008
Updated:: Dec.12, 2014
Registered:: Jul.11, 2014

Factors: (via ArrayExpress)

Sample	STATUS	AGE	DISEASE-FREE SURVIVAL TIME	SEX	RECURRENCE	T-STAGE	HISTOLOGY	N-STAGE	SMOKING	SURVIVAL TIME	STAGE
GSM1213849	alive	60.08	4.162	female	N	1	adenocarcinoma	0	Current	4.16	1A
GSM1213848	dead	76.25	0.099	female	N	2	adenocarcinoma	1	Ex-smoker	0.1	2B
GSM1213847	alive	76.07	8.263	male	N	1	adenocarcinoma	0	Never	8.26	1A
GSM1213846	dead	75.58	0.315	male	N	2	adenocarcinoma	0	Current	0.31	1B
GSM1213845	dead	71.84	1.035	female	Y	2	adenocarcinoma	1	Ex-smoker	1.2	2B
GSM1213844	alive	70.62	4.539	male	N	1	adenocarcinoma	0	Unable to determine	4.54	1A
GSM1213843	dead	61.07	7.737	male	N	2	squamous cell carcinoma	0	Current	7.74	1B
GSM1213842	dead	67	0.745	male	Y	2	Large Cell Carcinoma	0	Ex-smoker	1.05	1B
GSM121384	dead	73.45	2.927	male	Y	2	squamous cell carcinoma	1	Current	6.47	2B
GSM1213840	dead	65.69	0.016	female	U	1	adenocarcinoma	0	Unable to determine	1.23	1A
GSM1213839	dead	52.4	0.093	male	Y	2	squamous cell carcinoma	1	Never	1.35	2B
GSM1213838	alive	82.71	3.855	male	N	2	squamous cell carcinoma	1	Current	3.85	2B
GSM1213837	dead	74.09	7.608	female	N	2	adenocarcinoma	0	Current	7.61	1B
GSM1213836	alive	55.53	1.262	female	N	1	adenocarcinoma	1	Unable to determine	1.26	2A
GSM1213835	dead	85.48	1.881	male	Y	2	squamous cell carcinoma X2	0	Current	1.97	1B
GSM1213834	alive	68.32	2.708	female	N	2	adenocarcinoma	0	Unable to determine	2.71	1B
GSM1213833	dead	68.95	0.126	female	Y	2	adenocarcinoma	0	Ex-smoker	0.56	1B
GSM1213832	dead	68.7	1.667	male	N	2	Large Cell Carcinoma	1	Ex-smoker	1.67	2B
GSM121383	alive	76.71	5.125	male	N	2	adenocarcinoma	1	Unable to determine	5.13	2B
GSM1213830	alive	54.83	8.339	female	N	1	squamous cell carcinoma	0	Unable to determine	8.34	1A
GSM1213829	alive	63	1.369	female	N	1	squamous cell carcinoma	1	Unable to determine	1.37	2A
GSM1213828	dead	72.76	1.128	male	Y	1	squamous cell carcinoma	0	Unable to determine	2.49	1A
GSM1213827	alive	61.13	4.17	male	N	1	adenocarcinoma	0	Current	4.17	1A
GSM1213826	dead	71.7	0.569	male	N	2	adenocarcinoma	0	Ex-smoker	0.57	1B
GSM1213825	alive	64.13	7.381	female	N	1	adenocarcinoma	0	Ex-smoker	7.38	1A
GSM1213824	dead	70.73	1.591	female	N	2	adenocarcinoma	1	Ex-smoker	1.59	2B
GSM1213823	dead	73.55	3.647	male	Y	1	Large Cell Carcinoma	0	Ex-smoker	4.04	1A
GSM1213822	alive	55.68	12.036	female	N	2	squamous cell carcinoma	0	Unable to determine	12.04	1B
GSM121382	alive	64.6	11.392	male	N	2	squamous cell carcinoma	0	Ex-smoker	11.39	1B
GSM1213820	dead	67.62	1.906	female	N	2	adenocarcinoma	0	Unable to determine	1.91	1B
GSM1213819	dead	75.7	1.522	male	N	2	adenocarcinoma	0	Unable to determine	1.52	1B
GSM1213818	alive	84.95	3.379	female	N	2	adenocarcinoma	1	Ex-smoker	3.38	2B
GSM1213817	dead	69.62	3.461	male	N	2	squamous cell carcinoma	0	Ex-smoker	3.46	1B
GSM1213816	alive	70.56	0.093	male	N	2	adenocarcinoma	1	Unable to determine	0.09	2B
GSM1213815	alive	73.4	4.761	female	N	2	squamous cell carcinoma	1	Unable to determine	4.76	2B
GSM1213814	alive	70.82	5.103	female	N	2	adenocarcinoma	0	Ex-smoker	5.1	1B
GSM1213813	dead	71.35	0.947	male	N	2	squamous cell carcinoma	0	Unable to determine	0.95	1B
GSM1213812	dead	62.17	0.802	male	N	2	adenocarcinoma	1	Ex-smoker	0.8	2B
GSM12138	alive	62.68	1.372	male	N	1	adenocarcinoma	1	Ex-smoker	1.37	2A
GSM1213810	alive	70.38	0.153	female	N	2	adenocarcinoma	0	Never	0.15	1B
GSM1213809	alive	78.58	1.273	female	N	1	adenocarcinoma	0	Ex-smoker	1.27	1A
GSM1213808	alive	48.8	5.005	female	N	1	adenocarcinoma	0	Never	5	1A
GSM1213807	alive	69.92	0.706	male	N	2	adenocarcinoma	1	Current	0.71	2B
GSM1213806	alive	69.03	1.714	male	N	2	adenocarcinoma	0	Current	1.71	1B
GSM1213805	alive	47.09	6.021	male	N	2	adenocarcinoma	0	Ex-smoker	6.02	1B
GSM1213804	alive	80.83	7.833	female	N	2	adenocarcinoma	0	Unable to determine	7.83	1B
GSM1213803	alive	73.69	1.536	male	N	2	adenocarcinoma	0	Current	1.54	1B
GSM1213802	alive	63.8	4.726	female	N	2	squamous cell carcinoma	1	Current	4.73	2B
GSM121380	dead	76.94	0.027	male	U	1	adenocarcinoma	1	Ex-smoker	4.04	2A
GSM1213800	alive	84.48	0.515	female	N	1	adenocarcinoma	0	Never	0.51	1A
GSM1213799	dead	54.73	0.194	female	N	1	Large Cell Carcinoma	0	Current	0.19	1A
GSM1213798	alive	75.03	0.019	male	U	2	adenocarcinoma	0	Ex-smoker	10.88	1B
GSM1213797	alive	70.91	5.837	male	N	1	adenocarcinoma	0	Current	5.84	1A
GSM1213796	dead	61.86	5.604	male	N	2	squamous cell carcinoma	1	Ex-smoker	5.6	2B
GSM1213795	alive	60.29	6.675	female	N	1	adenocarcinoma	0	Unable to determine	6.67	1A
GSM1213794	alive	56.71	4.988	female	N	1	adenocarcinoma	0	Never	4.99	1A
GSM1213793	alive	72.67	2.686	female	N	2	adenocarcinoma	0	Never	2.69	1B
GSM1213792	dead	79.62	2.916	female	N	2	adenocarcinoma	0	Ex-smoker	2.92	1B
GSM121379	dead	69.07	0.077	female	U	1	squamous cell carcinoma	0	Current	5.18	1A
GSM1213790	alive	67.29	5.183	female	N	2	squamous cell carcinoma	0	Current	5.18	1B
GSM1213789	dead	80.34	0.709	male	Y	2	squamous cell carcinoma	0	Ex-smoker	1.83	1B
GSM1213788	dead	80.54	1.191	male	Y	2	adenocarcinoma	1	Ex-smoker	1.49	2B
GSM1213787	alive	71.22	2.913	female	Y	2	adenocarcinoma	0	Never	3.43	1B
GSM1213786	alive	73.79	5.958	female	N	2	squamous cell carcinoma	0	Ex-smoker	5.96	1B
GSM1213785	dead	73.63	2.94	male	Y	1	adenocarcinoma	0	Unable to determine	3.89	1A
GSM1213784	alive	66.38	5.205	male	N	1	adenocarcinoma	0	Ex-smoker	5.2	1A
GSM1213783	dead	83.58	0.6	female	N	1	adenocarcinoma	0	Ex-smoker	0.6	1A
GSM1213782	alive	74.74	3.214	male	N	1	adenocarcinoma	0	Ex-smoker	3.21	1A
GSM121378	dead	70.96	1.796	male	N	2	adenocarcinoma	1	Ex-smoker	1.8	2B
GSM1213780	dead	84.19	0.654	male	N	1	adenocarcinoma	0	Unable to determine	0.65	1A
GSM1213779	alive	73.02	3.107	female	N	2	adenocarcinoma	0	Current	3.11	1B
GSM1213778	alive	67.64	5.667	female	N	1	squamous cell carcinoma	0	Current	5.67	1A
GSM1213777	alive	66.69	5.446	male	N	2	adenocarcinoma	0	Ex-smoker	5.45	1B
GSM1213776	dead	70.73	1.213	female	N	2	NSCLC-favor adenocarcinoma	1	Unable to determine	1.21	2B
GSM1213775	dead	70.52	3.143	male	N	1	adenocarcinoma	0	Current	3.14	1A
GSM1213774	dead	68.25	2.888	male	Y	2	adenocarcinoma	1	Current	3.01	2B
GSM1213773	dead	69.43	4.794	female	N	2	adenocarcinoma	0	Ex-smoker	4.79	1B
GSM1213772	alive	87.93	7.436	male	N	2	squamous cell carcinoma	0	Ex-smoker	7.44	1B
GSM121377	alive	83.87	7.384	female	N	2	squamous cell carcinoma	1	Ex-smoker	7.38	2B
GSM1213770	dead	68.59	2.108	male	N	2	adenocarcinoma	1	Ex-smoker	2.11	2B
GSM1213769	alive	57.75	3.721	female	Y	1	adenocarcinoma	0	Ex-smoker	5.29	1A
GSM1213768	alive	60.6	4.345	male	N	2	adenocarcinoma	0	Current	4.34	1B
GSM1213767	dead	73.25	3.641	male	N	2	squamous cell carcinoma	0	Unable to determine	3.64	1B
GSM1213766	dead	87.11	3.48	male	N	2	squamous cell carcinoma	0	Current	3.48	1B
GSM1213765	dead	73.23	2.7	male	N	2	squamous cell carcinoma	0	Unable to determine	2.7	1B
GSM1213764	alive	63.54	7.745	female	N	2	adenocarcinoma	0	Never	7.75	1B
GSM1213763	dead	62.23	1.955	female	N	2	adenocarcinoma	0	Current	1.95	1B
GSM1213762	dead	57.68	0.112	female	Y	3	adenocarcinoma	0	Current	0.86	2B
GSM121376	alive	63.1	4.928	female	N	1	adenocarcinoma	0	Current	4.93	1A
GSM1213760	alive	78.11	4.575	female	N	1	adenocarcinoma	0	Ex-smoker	4.57	1A
GSM1213759	alive	49.41	5.495	male	N	2	adenocarcinoma	0	Current	5.49	1B
GSM1213758	alive	61.98	2.119	male	Y	2	adenocarcinoma	0	Ex-smoker	5.51	1B
GSM1213757	alive	69.77	0.274	male	Y	2	adenocarcinoma	0	Ex-smoker	5.75	1B
GSM1213756	alive	60.85	5.273	male	N	1	adenocarcinoma	0	Ex-smoker	5.27	1A
GSM1213755	alive	71.5	5.322	male	N	1	Large Cell Carcinoma	0	Ex-smoker	5.32	1A
GSM1213754	dead	72.96	0.701	male	Y	2	adenocarcinoma	1	Current	2.02	2B
GSM1213753	dead	80.78	2.732	female	Y	2	adenocarcinoma	0	Current	3.09	1B
GSM1213752	dead	64.73	0.821	male	Y	2	adenocarcinoma	0	Ex-smoker	0.97	1B
GSM121375	alive	49.86	4.912	female	N	1	adenocarcinoma	0	Ex-smoker	4.91	1A
GSM1213750	dead	50.12	0.923	male	Y	2	adenocarcinoma	1	Current	1.03	2B
GSM1213749	dead	78.26	1.216	male	Y	2	adenocarcinoma	0	Never	3.2	1B
GSM1213748	alive	60.7	5.079	female	N	1	squamous cell carcinoma	0	Current	5.08	1A
GSM1213747	alive	57.09	4.129	female	N	1	adenocarcinoma	1	Ex-smoker	4.13	2A
GSM1213746	alive	60.79	5.175	male	N	2	adenocarcinoma	0	Current	5.17	1B
GSM1213745	dead	63.21	4.758	male	Y	2	adenosquamous carcinoma	1	Current	4.76	2B
GSM1213744	alive	71.47	5.043	male	N	1	squamous cell carcinoma	0	Ex-smoker	5.04	1A
GSM1213743	alive	40.16	5.032	female	N	2	adenocarcinoma	0	Never	5.03	1B
GSM1213742	dead	80.76	5.259	male	N	2	adenocarcinoma	1	Ex-smoker	5.26	2B
GSM121374	dead	80.61	6.352	male	N	2	adenocarcinoma	0	Never	6.35	1B
GSM1213740	alive	85.91	5.843	female	N	2	adenocarcinoma	0	Never	5.84	1B
GSM1213739	alive	74.91	0.12	female	N	2	adenocarcinoma	0	Ex-smoker	0.12	1B
GSM1213738	dead	63.5	3.852	male	N	1	adenocarcinoma	1	Current	3.85	2A
GSM1213737	alive	64.19	2.946	female	N	1	adenocarcinoma	0	Never	2.95	1A
GSM1213736	dead	54.09	0.887	female	Y	2	adenocarcinoma	0	Ex-smoker	0.91	1B
GSM1213735	alive	68.14	1.232	female	Y	2	adenocarcinoma	0	Ex-smoker	6.06	1B
GSM1213734	alive	71.23	5.161	female	N	2	adenocarcinoma	1	Ex-smoker	5.16	2B
GSM1213733	dead	78.13	2.708	male	Y	2	adenocarcinoma	0	Current	3.48	1B
GSM1213732	alive	74.13	7.556	male	N	1	squamous cell carcinoma	0	Current	7.56	1A
GSM121373	alive	69.17	5.81	male	N	2	squamous cell carcinoma	1	Ex-smoker	5.81	2B
GSM1213730	dead	65.26	0.799	male	Y	2	adenocarcinoma	0	Ex-smoker	3.21	1B
GSM1213729	dead	69.7	1.933	male	Y	2	squamous cell carcinoma	0	Ex-smoker	2.42	1B
GSM1213728	alive	75.89	5.388	male	N	1	adenocarcinoma	0	Ex-smoker	5.39	1A
GSM1213727	dead	49.24	1.791	male	Y	1	adenocarcinoma	1	Current	5.79	2A
GSM1213726	alive	83.65	6.563	female	N	2	adenocarcinoma	1	Ex-smoker	6.56	2B
GSM1213725	alive	71.92	6.434	female	N	2	Large Cell Carcinoma	0	Current	6.43	1B
GSM1213724	alive	76.91	6.283	male	N	1	adenocarcinoma	0	Ex-smoker	6.28	1A
GSM1213723	dead	79.65	2.229	male	Y	2	adenocarcinoma	1	Ex-smoker	2.61	2B
GSM1213722	dead	68.87	0.583	female	Y	2	adenocarcinoma	0	Current	1.25	1B
GSM121372	alive	57.41	6.111	male	N	2	NSClarge cell carcinoma-mixed	0	Current	6.11	1B
GSM1213720	alive	67.6	6.371	male	N	1	adenocarcinoma	0	Ex-smoker	6.37	1A
GSM1213719	dead	72.55	0.808	male	Y	2	squamous cell carcinoma	0	Ex-smoker	0.93	1B
GSM1213718	alive	81.17	4.947	female	N	2	squamous cell carcinoma	0	Ex-smoker	4.95	1B
GSM1213717	dead	63.41	3.608	male	Y	2	adenocarcinoma	0	Ex-smoker	4.91	1B
GSM1213716	dead	73.57	4.367	male	Y	2	adenocarcinoma	0	Ex-smoker	4.37	1B
GSM1213715	alive	72.97	4.022	female	Y	2	adenocarcinoma	1	Ex-smoker	7.36	2B
GSM1213714	alive	62.91	6.149	female	N	2	squamous cell carcinoma	1	Ex-smoker	6.15	2B
GSM1213713	alive	70.52	4.945	male	N	2	Large Cell Carcinoma	0	Current	4.94	1B
GSM1213712	alive	69.07	6.582	female	N	2	squamous cell carcinoma	0	Ex-smoker	6.58	1B
GSM12137	alive	70.85	4.624	female	N	2	squamous cell carcinoma	1	Current	4.62	2B
GSM1213710	alive	67.56	0.214	male	Y	2	adenocarcinoma	1	Current	0.33	2B
GSM1213709	alive	77.27	4.679	female	Y	2	squamous cell carcinoma	0	Current	5.2	1B
GSM1213708	alive	63.1	5.227	male	Y	1	squamous cell carcinoma	1	Ex-smoker	6.11	2A
GSM1213707	alive	41.95	1.725	female	Y	2	adenocarcinoma	0	Never	5.41	1B
GSM1213706	alive	49.53	7.499	male	N	2	squamous cell carcinoma	1	Ex-smoker	7.5	2B
GSM1213705	dead	59.11	0.287	male	Y	2	squamous cell carcinoma	1	Ex-smoker	0.48	2B
GSM1213704	alive	61.59	4.964	male	Y	2	adenocarcinoma	1	Never	5.54	2B
GSM1213703	dead	75.68	5.752	female	Y	2	adenocarcinoma	0	Never	5.96	1B
GSM1213702	dead	55.75	2.927	male	N	3	adenocarcinoma	0	Current	2.93	2B
GSM121370	dead	73.66	5.194	male	Y	1	squamous cell carcinoma	0	Current	5.22	1A
GSM1213700	dead	73.93	1.87	female	Y	2	adenocarcinoma	0	Never	4.03	1B
GSM1213699	dead	61.13	1.325	male	Y	1	adenocarcinoma	0	Never	1.88	1A
GSM1213698	dead	69.59	5.634	female	N	2	adenocarcinoma	1	Current	5.63	2B
GSM1213697	alive	79.71	6.368	male	N	2	adenocarcinoma	0	Current	6.37	1B
GSM1213696	alive	67.04	5.18	male	N	2	adenocarcinoma	0	Ex-smoker	5.18	1B
GSM1213695	alive	62.9	5.843	female	N	2	adenocarcinoma	1	Current	5.84	2B
GSM1213694	alive	68.66	3.102	female	Y	1	adenocarcinoma	1	Never	6.69	2A
GSM1213693	dead	61.53	0.709	female	Y	2	adenocarcinoma	1	Current	1.1	2B
GSM1213692	dead	55.39	5.744	female	N	1	adenocarcinoma	0	Never	5.74	1A
GSM121369	alive	78.99	6.393	male	N	2	adenocarcinoma	0	Current	6.39	1B
GSM1213690	alive	78.96	4.882	female	Y	2	adenocarcinoma	1	Ex-smoker	5.12	2B
GSM1213689	alive	77.18	4.95	female	N	1	adenocarcinoma	0	Never	4.95	1A
GSM1213688	alive	73.23	5.758	male	N	1	adenocarcinoma	0	Ex-smoker	5.76	1A
GSM1213687	alive	76.93	6.456	male	N	2	adenocarcinoma	0	Current	6.46	1B
GSM1213686	dead	85.78	2.836	male	N	2	adenocarcinoma	0	Ex-smoker	2.84	1B
GSM1213685	alive	52.14	6.757	male	N	1	adenocarcinoma	0	Current	6.76	1A
GSM1213684	alive	73.26	3.466	female	N	2	squamous cell carcinoma	1	Ex-smoker	3.47	2B
GSM1213683	alive	79.28	5.018	male	N	2	adenocarcinoma	0	Ex-smoker	5.02	1B
GSM1213682	alive	72.96	5.561	female	N	1	adenocarcinoma	0	Ex-smoker	5.56	1A
GSM121368	alive	70.56	5.317	female	N	2	adenocarcinoma	0	Ex-smoker	5.32	1B
GSM1213680	alive	59.01	5.988	female	N	2	adenocarcinoma	0	Ex-smoker	5.99	1B
GSM1213679	alive	66.46	6.311	male	N	1	adenocarcinoma	0	Ex-smoker	6.31	1A
GSM1213678	dead	74.16	3.743	female	Y	2	adenocarcinoma	1	Never	4.08	2B
GSM1213677	alive	44.21	6.218	female	N	2	adenocarcinoma	0	Never	6.22	1B
GSM1213676	dead	71.43	4.156	male	Y	2	adenocarcinoma	0	Ex-smoker	4.33	1B
GSM1213675	alive	63.63	6.85	female	N	2	squamous cell carcinoma	1	Ex-smoker	6.85	2B
GSM1213674	alive	57.31	7.034	male	N	2	squamous cell carcinoma	0	Current	7.03	1B
GSM1213673	dead	68	1.613	male	Y	2	adenocarcinoma	0	Current	1.91	1B
GSM1213672	alive	82.36	6.842	female	N	1	adenocarcinoma	0	Ex-smoker	6.84	1A
GSM121367	alive	69.15	7.324	male	N	2	adenocarcinoma	0	Current	7.32	1B
GSM1213670	alive	68.15	7.521	female	N	1	adenocarcinoma	0	Current	7.52	1A
GSM1213669	dead	63.57	4.115	male	N	1	adenosquamous carcinoma	0	Current	4.11	1A