{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM1210768": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210768": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210768": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210768": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210764": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210764": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210764": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210764": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210768": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210764": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210758": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "not specified"}}, {"GSM1210758": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "not specified"}}, {"GSM1210758": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "not specified"}}, {"GSM1210758": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "not specified"}}, {"GSM1210758": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD8+ T-cells", "HCV VIRAL LOAD": "not specified"}}, {"GSM1210753": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210753": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210753": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210753": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210749": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210749": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210749": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210749": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210753": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "low (HCV-l)"}}, {"GSM1210749": {"SAMPLE GROUP": "long-term treatment-na\u00ef\u00bf\u00bdve chronic HCV (CHC) patients", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "high (HCV-h)"}}, {"GSM1210743": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "not specified"}}, {"GSM1210743": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "not specified"}}, {"GSM1210743": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "not specified"}}, {"GSM1210743": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "not specified"}}, {"GSM1210743": {"SAMPLE GROUP": "healthy donors (HD)", "CELL TYPE": "CD4+ T-cells", "HCV VIRAL LOAD": "not specified"}}], "id": 2318, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Although extensive studies have demonstrated the gene expression patterns of antigen-specific CD4+ and CD8+ T-cells during chronic...", "geo_gse_id": "E-GEOD-49954", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 30, "tags": ["chronic hepatitis", "chronic hepatitis c"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "t-lymphocytes-from-chronic-hcv-infected-patients-e", "geo_id_plat": "E-GEOD-49954_A-AFFY-44", "name": "T lymphocytes from Chronic HCV-infected patients express unique pro-apoptotic gene signature.", "created": "Jul.12, 2014", "summary": "Although extensive studies have demonstrated the gene expression patterns of antigen-specific CD4+ and CD8+ T-cells during chronic hepatitis C virus (HCV) infection, the transcriptional profiles of global CD4+ and CD8+ T-cells remains unclear. In this report, we recruited 10 long-term (~20 years) treatment-na\u00efve chronic HCV (CHC) patients and 5 healthy donors (HDs) to investigate differences in global CD4+ and CD8+ T-cells gene expression profile. Global CD4+ and CD8+ T-cells showed unique transcriptional profiles in the expression of apoptosis-related genes. We identified BCL2, PMAIP1, and CASP1 in CD4+ T-cells and IER3 and BCL2A1 in CD8+ T-cells from CHC patients as HCV-specific gene signatures. The unique apoptosis-related gene expression profilesin global CD4+ and CD8+ T-cells  programmed by chronic HCV infection seemed to enhance activation-induced apoptosis, which was suffered by  global CD4+ and CD8+ T-cells. We obtained 15 blood samples to identify the gene expression signatures of global CD4+ and CD8+ T-cells due to chronic HCV infection. The samples included: 5 samples from high HCV viral load patients (HCV-h), 5 samples from low HCV viral load (HCV-l) and 5 samples from healthy donors (HD). HCV patients were all Ab+ and treatment-naive prior to the study. Samples were taken once from each individual. Global CD4+ and CD8+ T-cells were enriched by microbeads, and total RNA were used in gene chip analysis.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49954", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49954/samples/"}