{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, {"GSM1209033": {"MIR-150 LEVEL": "low"}}, 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{"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}, {"GSM120910": {"MIR-150 LEVEL": "high"}}], "id": 4676, "pop_total": 0, "platform": 4, "summary_wrapped": "[u'We examined the microRNAs (miRNAs) expressed in chronic lymphocytic leukemia (CLL) and identified miR-150 as the most abundant, but...", "pubmed_id": 24787006, "geo_gse_id": "E-GEOD-49896", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 100, "tags": ["cell", "chronic lymphocytic leukemia", "disease", "leukemia", "median", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "microrna-150-contributes-to-the-proficiency-of-b-c", "geo_id_plat": "E-GEOD-49896_A-AFFY-44", "name": "MicroRNA-150 Contributes to the Proficiency of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia by Regulating Expression of GAB1 and FOXP1 Genes", "created": "Sep.21, 2014", "summary": "[u'We examined the microRNAs (miRNAs) expressed in chronic lymphocytic leukemia (CLL) and identified miR-150 as the most abundant, but with leukemia-cell-expression levels that varied among patients. CLL cells that expressed ZAP-70 or that used unmutated IGHV each had a median expression-level of miR-150 that was significantly lower than that of ZAP-70-negative CLL cells or those that used mutated IGHV. In samples stratified for expression of miR-150, CLL cells with low-level miR-150 expressed relatively higher levels of forkhead box P1 (FOXP1) and GRB2-associated binding protein 1 (GAB1), genes with 3\\u2019 UTRs having evolutionary-conserved binding sites for miR-150. High-level expression of miR-150 could repress expression of these genes, which encode proteins that may enhance B-cell receptor (BCR) signaling, a putative CLL-growth/survival signal. Also, high-level expression of miR-150 levels was a significant independent predictor of longer treatment-free-survival (TFS) or overall survival (OS), whereas an inverse association was observed for high-level expression of GAB1 or FOXP1 for OS. This study demonstrates that expression of miR-150 can influence the relative expression of GAB1 and FOXP1 and the signaling potential of the B-cell receptor (BCR), thereby possibly accounting for the noted association of expression of miR-150 and disease outcome. We performed gene expression analysis on isolated leukemia cells from 100 CLL patients using the Affymetrix HG-U133 Plus 2 platform. Array data was processed by dChip software (', {u'a': {u'href': u'http://www.dchip.org', u'target': u'_blank', u'$': u'http://www.dchip.org'}}, u'). No techinical replicates were performed.']", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49896", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49896/samples/"}