{"platform": 8, "owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1209022": {"CHROMOSOME STABILITY": "unstable", "BUBR1 ALLELE": "Hypomorphic", "CDC20 ALLELE": "wild type"}}, {"GSM1209023": {"CHROMOSOME STABILITY": "stable", "BUBR1 ALLELE": "wild type", "CDC20 ALLELE": "wild type"}}, {"GSM1209022": {"CHROMOSOME STABILITY": "unstable", "BUBR1 ALLELE": "Hypomorphic", "CDC20 ALLELE": "wild type"}}, {"GSM1209023": {"CHROMOSOME STABILITY": "stable", "BUBR1 ALLELE": "wild type", "CDC20 ALLELE": "wild type"}}, {"GSM1209023": {"CHROMOSOME STABILITY": "stable", "BUBR1 ALLELE": "wild type", "CDC20 ALLELE": "wild type"}}, {"GSM1209027": {"CHROMOSOME STABILITY": "unstable", "BUBR1 ALLELE": "wild type", "CDC20 ALLELE": "Hypomorphic"}}], "id": 8723, "ownerprofile_id": "arrayexpress_sid", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49894", "summary_wrapped": "In all primary cells analyzed to date, aneuploidy is associated with poor proliferation.  Yet, how abnormal karyotypes affect cancer \u2013 a...", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 6, "tags": ["cancer", "cell", "disease", "embryo", "fibroblast"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "a-transcriptional-and-metabolic-signature-of-prima", "geo_id_plat": "E-GEOD-49894_A-AFFY-36", "name": "A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally-unstable cancer cells and informs clinical prognosis", "created": "Nov.24, 2014", "summary": "In all primary cells analyzed to date, aneuploidy is associated with poor proliferation.  Yet, how abnormal karyotypes affect cancer \u2013 a disease characterized by both aneuploidy and heightened proliferative capacity \u2013 is largely unknown.  Here, I demonstrate that the transcriptional alterations caused by aneuploidy in primary cells are also present in chromosomally-unstable cancer cell lines, but are not common to all aneuploid cancers.  Moreover, chromosomally-unstable cancer lines display increased glycolytic and TCA-cycle flux, as is also observed in primary aneuploid cells.  The biological response to aneuploidy is associated with cellular stress and slow proliferation, and a 70-gene signature derived from primary aneuploid cells is a strong predictor of increased survival in several cancers.  Inversely, a transcriptional signature derived from clonal aneuploidy in tumors correlates with high mitotic activity and poor prognosis.  I speculate that there are two types of aneuploidy in cancer: clonal aneuploidy, which is selected during tumor evolution and is associated with robust growth, and sub-clonal aneuploidy, which is caused by chromosomal instability (CIN) and more closely resembles the stressed state of primary aneuploid cells.  Nonetheless, CIN is not benign: a subset of genes upregulated in high-CIN cancers predict aggressive disease in human patients in a proliferation-independent manner. The mRNAs from 3 different mouse embryo fibroblast (MEF) lines that are chromosomally stable were compared with mRNAs from 3 different MEF lines that were chromosomally unstable due to mutations in either BUBR1 or CDC20", "geo_gse_id": "E-GEOD-49894", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49894/samples/"}