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"H3.3_STATUS": "K27M", "AGE": "8", "AGE AT DIAGNOSIS YEARS": "not specified", "SEX": "female", "LOCATION": "not specified", "IDH1 STATUS": "not specified", "SUBGROUP": "not specified"}}, {"GSM855967": {"H3F3A STATUS": "not specified", "TUMOR LOCATION": "not specified", "H3.3_STATUS": "K27M", "AGE": "6", "AGE AT DIAGNOSIS YEARS": "not specified", "SEX": "female", "LOCATION": "not specified", "IDH1 STATUS": "not specified", "SUBGROUP": "not specified"}}, {"GSM855966": {"H3F3A STATUS": "not specified", "TUMOR LOCATION": "not specified", "H3.3_STATUS": "K27M", "AGE": "11", "AGE AT DIAGNOSIS YEARS": "not specified", "SEX": "male", "LOCATION": "not specified", "IDH1 STATUS": "not specified", "SUBGROUP": "not specified"}}, {"GSM855963": {"H3F3A STATUS": "not specified", "TUMOR LOCATION": "not specified", "H3.3_STATUS": "wt", "AGE": "14", "AGE AT DIAGNOSIS YEARS": "not specified", "SEX": "male", "LOCATION": "not specified", "IDH1 STATUS": "not specified", "SUBGROUP": "not specified"}}, {"GSM855957": {"H3F3A STATUS": "not specified", "TUMOR LOCATION": "not specified", "H3.3_STATUS": "K27M", "AGE": "10", "AGE AT DIAGNOSIS YEARS": "not specified", "SEX": "male", "LOCATION": "not specified", "IDH1 STATUS": "not specified", "SUBGROUP": "not specified"}}, {"GSM855963": {"H3F3A STATUS": "not specified", "TUMOR LOCATION": "not specified", "H3.3_STATUS": "wt", "AGE": "14", "AGE AT DIAGNOSIS YEARS": "not specified", "SEX": "male", "LOCATION": "not specified", "IDH1 STATUS": "not specified", "SUBGROUP": "not specified"}}, {"GSM855947": {"H3F3A STATUS": "not specified", "TUMOR LOCATION": "not specified", "H3.3_STATUS": "K27M", "AGE": "5", "AGE AT DIAGNOSIS YEARS": "not specified", "SEX": "male", "LOCATION": "not specified", "IDH1 STATUS": "not specified", "SUBGROUP": "not specified"}}], "id": 2035, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Pediatric high-grade gliomas (pHGGs) harboring the K27M mutation of H3F3A (histone H3.3) are characterized by global reduction of the...", "pubmed_id": 24183680, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 9, "sample_count": 22, "tags": ["genome", "histone", "histone h3"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-49822_A-AFFY-44", "slug": "gene-expression-data-of-phgg-tumor-samples", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49822", "geo_gds_id": "", "name": "Gene expression data of pHGG tumor samples", "created": "Jul.10, 2014", "summary": "Pediatric high-grade gliomas (pHGGs) harboring the K27M mutation of H3F3A (histone H3.3) are characterized by global reduction of the repressive histone mark H3K27me3 and DNA hypomethylation. Analysis of K27M-induced changes on H3K27me3 occupancy and DNA methylation at differentially expresed genes (K27M vs. wild-type H3.3) in primary pHGG tumor samples. 22 glioblastoma samples from pHGG patients were selected for RNA extraction and hybridization on Affymetrix Affymetrix Human Genome U133 Plus 2.0 Arrays. Expression profiling data of 17 pHHGs are part of our previous study (GSE36245 or GSE34824).", "geo_gse_id": "E-GEOD-49822", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49822/samples/"}