ArrayExpress Uploader0human1Left colonpT3Primary Tumor51femaleWellpN211Left colonpT3Normal Colon51femaleWellpN211Left colonpT3Liver Metastasis51femaleWellpN217Rectum-sigmoid junctionpT3Liver Metastasis53malenot specifiedpN0not specified8Left colonpT3Liver Metastasis49maleModeratepN2021Left colonpT3Primary Tumor68femaleWellpN2121Left colonpT3Normal Colon68femaleWellpN2130Left colonpT4Normal Colon72malenot specifiedpN0042Left colonpT4Liver Metastasis50femaleWellpN1142Left colonpT4Normal Colon50femaleWellpN1142Left colonpT4Primary Tumor50femaleWellpN1143Left colonpT3Primary Tumor71maleWellpN2150rectumpT3Liver Metastasis68maleWellpN2051Left colonpT4Liver Metastasis65maleModeratepN0051Left colonpT4Primary Tumor65maleModeratepN0056Left colonpT3Liver Metastasis60maleWellpN2056Left colonpT3Primary Tumor60maleWellpN2056Left colonpT3Normal Colon60maleWellpN2064Left colonpT3Primary Tumor64maleModeratepN2064Left colonpT3Normal Colon64maleModeratepN2077Left colonpT3Normal Colon62maleWellpN2177Left colonpT3Liver Metastasis62maleWellpN2177Left colonpT3Primary Tumor62maleWellpN2193Rectum-sigmoid junctionpT4Liver Metastasis50malePoorpN2193Rectum-sigmoid junctionpT4Primary Tumor50malePoorpN2194transverse colonpT4Normal Colon64femaleModeratepN2094transverse colonpT4Liver Metastasis64femaleModeratepN20103rectumpT4Liver Metastasis54maleWellpN10108Right colonpT3Normal Colon45femaleModeratepN21108Right colonpT3Liver Metastasis45femaleModeratepN21108Right colonpT3Primary Tumor45femaleModeratepN21109Left colonpT3Normal Colon69femalenot specifiedpN20109Left colonpT3Primary Tumor69femalenot specifiedpN20123Left colonpT3Primary Tumor56femalePoorpN20141Left colonpT3Primary Tumor57maleWellpN00141Left colonpT3Liver Metastasis57maleWellpN00141Left colonpT3Normal Colon57maleWellpN00174rectumnot specifiedLiver Metastasis76malenot specifiednot specified0178Left colonpT3Normal Colon54maleWellpN01178Left colonpT3Primary Tumor54maleWellpN01185Left colonpT3Liver Metastasis60femaleWellpN10185Left colonpT3Primary Tumor60femaleWellpN10185Left colonpT3Normal Colon60femaleWellpN10202Left colonpT3Liver Metastasis53femaleModeratepN11202Left colonpT3Normal Colon53femaleModeratepN11202Left colonpT3Primary Tumor53femaleModeratepN11209Left colonpT3Liver Metastasis52maleModeratepN01209Left colonpT3Primary Tumor52maleModeratepN01209Left colonpT3Normal Colon52maleModeratepN01211Left colonpT4Normal Colon61malePoorpN21211Left colonpT4Primary Tumor61malePoorpN21234caecumpT3Normal Colon57femaleModeratepN1not specified238Left colonpT3Primary Tumor70maleModeratepN20238Left colonpT3Liver Metastasis70maleModeratepN20238Left colonpT3Normal Colon70maleModeratepN20261transverse colonpT3Primary Tumor59femaleModeratepN11261transverse colonpT3Liver Metastasis59femaleModeratepN119709arrayexpress_sid3To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and...E-GEOD-49355/profile/8773/arrayexpressuploader057breastbreast cancercancercellcoloncolon cancercolorectal cancerlivermucosaJan.17, 2015Falsespecific-extracellular-matrix-remodeling-signatureE-GEOD-49355_A-AFFY-33Specific extracellular matrix remodeling signature of colon hepatic metastasesJan.17, 2015To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. The identified genes are specific to colon cancer and hepatic metastases since other metastatic locations and hepatic metastases originating from breast cancer were not classified by the signature. Gene Ontology term analysis showed that 50% of the genes are implicated in extracellular matrix remodeling, and more precisely in cell adhesion, extracellular matrix organization and angiogenesis. Because of the high efficiency of the signature to classify colon hepatic metastases, the identified genes represent promising targets to develop new therapies that will specifically affect hepatic metastasis microenvironment. 57 samples of patients with stage IV colorectal cancer. We compared using Affymetrix chips gene expression profiles between primary tumors and hepatic metastaseshttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49355http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-49355/samples/