{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 7368, "factors": [{"GSM1185161 1": {}}, {"GSM1185162 1": {}}, {"GSM1185163 1": {}}, {"GSM1185164 1": {}}, {"GSM1185165 1": {}}, {"GSM1185166 1": {}}, {"GSM1185167 1": {}}, {"GSM1185168 1": {}}, {"GSM1185169 1": {}}, {"GSM1185170 1": {}}, {"GSM1185171 1": {}}, {"GSM1185172 1": {}}, {"GSM1185173 1": {}}, {"GSM1185174 1": {}}, {"GSM1185175 1": {}}, {"GSM1185176 1": {}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "MicroRNA regulates protein expression of cells by repressing translation of specific target messenger transcripts. Loss of the neuron...", "pubmed_id": 24311694, "geo_gse_id": "E-GEOD-48813", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 16, "tags": ["dopamine", "epilepsy", "neuron", "protein", "ribosome", "striatum"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-changes-in-the-absence-of-mir-128-in-st", "geo_id_plat": "E-GEOD-48813_A-AFFY-45", "name": "Expression changes in the absence of miR-128 in striatal D1-receptor positive neurons", "created": "Nov.12, 2014", "summary": "MicroRNA regulates protein expression of cells by repressing translation of specific target messenger transcripts. Loss of the neuron specific microRNA miR-128 in Dopamine D1-receptor expressing neurons in the murine striatum (D1-MSNs) lead to increased neuronal excitability, locomotor hyperactivity and fatal epilepsy. To examine expression changes in the absence of miR-128 in D1-MSNs, we used mice expressing EGFP-tagged ribosomes in D1-MSNs with either D1-MSN-specific homozygous deletion of miR-128-2 locus or no deletion. Transcripts co-immunoprecipitated with tagged ribosomes were analyzed by microarray. 9 mutant animals ( D1-MSN-tagged ribosome; D1-MSN specific miR-128-2 homozygous deletion) and 7 age matched littermate control animals (D1-MSN-tagged ribosome only).", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-48813", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-48813/samples/"}