{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 7353, "factors": [{"GSM1172707": {"AGE": "28 weeks", "GENOTYPE": "R26NC/NC CD4Cre+", "CELL TYPE": "tumoral thymocytes"}}, {"GSM1172708": {"AGE": "26 weeks", "GENOTYPE": "R26NC/NC CD4Cre+", "CELL TYPE": "tumoral thymocytes"}}, {"GSM1172709": {"AGE": "23 weeks", "GENOTYPE": "R26NC/NC CD4Cre+", "CELL TYPE": "tumoral thymocytes"}}, {"GSM1172710": {"AGE": "21 weeks", "GENOTYPE": "R26NC/NC CD4Cre+", "CELL TYPE": "tumoral thymocytes"}}, {"GSM11727": {"AGE": "6 weeks", "GENOTYPE": "R26NC/NC CD4Cre-", "CELL TYPE": "purified CD8+CD4+ thymocytes"}}, {"GSM11727": {"AGE": "6 weeks", "GENOTYPE": "R26NC/NC CD4Cre-", "CELL TYPE": "purified CD8+CD4+ thymocytes"}}, {"GSM1172713": {"AGE": "6 weeks", "GENOTYPE": "R26NC/NC CD4Cre+", "CELL TYPE": "purified CD8+CD4+ thymocytes"}}, {"GSM1172713": {"AGE": "6 weeks", "GENOTYPE": "R26NC/NC CD4Cre+", "CELL TYPE": "purified CD8+CD4+ thymocytes"}}, {"GSM1172713": {"AGE": "6 weeks", "GENOTYPE": "R26NC/NC CD4Cre+", "CELL TYPE": "purified CD8+CD4+ thymocytes"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "To assess the importance of the Wnt pathway during T cell develoment, we generated a mouse line (R26-\u03b2cat) in which high levels of active...", "pubmed_id": 23801632, "geo_gse_id": "E-GEOD-48203", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 9, "tags": ["cell", "line", "thymocyte", "thymus"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-tumoral-thymocytes-and-dp-thy", "geo_id_plat": "E-GEOD-48203_A-AFFY-45", "name": "Expression data from tumoral thymocytes and DP thymocytes expressing an activated form of b-catenin in mouse T cells", "created": "Nov.12, 2014", "summary": "To assess the importance of the Wnt pathway during T cell develoment, we generated a mouse line (R26-\u03b2cat) in which high levels of active \u03b2-catenin are maintained throughout T cell development. Young R26-\u03b2cat mice (6-week-old) show a differentiation block at the CD4+CD8+ DP stage. All R26-\u03b2cat mice develop T cell leukemias with a DP phenotype at 5-6 months of age. To identify the molecular pathways involved in tumor development, we profiled the global gene expression of transformed and pre-transformed DP cells. Thymocytes from 6-week-old mice (with a normal sized thymus and a polyclonal thymocyte population) were used to define the pre-transformed transcriptome. RNA from control and pre-leukemic R26-\u03b2cat DP thymocytes as well as R26-\u03b2cat total tumor cells were extracted and used for transcriptome analysis.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-48203", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-48203/samples/"}