Dataset: Regulation of Mouse Lens Development and Gene Expression by Krüppel-Like Factor 4
Conditional disruption of Klf4 in the ectoderm-derived tissues of the eye results in defective cornea, conjunctiva and the lens....
Conditional disruption of Klf4 in the ectoderm-derived tissues of the eye results in defective cornea, conjunctiva and the lens. Expression of Klf4 is first detected in the embryonic day-12 (E12) mouse lens, peaks at E16, and declines thereafter. Lenses from Mice which were conditional null for Klf4 (Klf4CN) were characterized by morphology and transcriptome. Wild type and Klf4-conditional null mouse lens gene expression at embryonic day 16.5 (E16.5) and postnatal day 56 (PN56) was surveyed using Affymetrix mouse whole genome 430 2 arrays.
- Species:
- mouse
- Samples:
- 10
- Source:
- E-GEOD-47694
- Updated:
- Dec.12, 2014
- Registered:
- Nov.12, 2014
Factors:
(via ArrayExpress)
| Sample | AGE | GENOTYPE |
|---|---|---|
| GSM1155018 | embryonic day 16.5 | wild type |
| GSM1155018 | embryonic day 16.5 | wild type |
| GSM1155018 | embryonic day 16.5 | wild type |
| GSM115502 | embryonic day 16.5 | Klf4-conditional null |
| GSM115502 | embryonic day 16.5 | Klf4-conditional null |
| GSM115502 | embryonic day 16.5 | Klf4-conditional null |
| GSM1155024 | Postnatal day 56 | wild type |
| GSM1155024 | Postnatal day 56 | wild type |
| GSM1155026 | Postnatal day 56 | Klf4-conditional null |
| GSM1155026 | Postnatal day 56 | Klf4-conditional null |