{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "id": 2314, "factors": [{"GSM1152663": {"ORGANISM PART": "myometrium"}}, {"GSM1152663": {"ORGANISM PART": "myometrium"}}, {"GSM1152663": {"ORGANISM PART": "myometrium"}}, {"GSM1152663": {"ORGANISM PART": "myometrium"}}, {"GSM1152663": {"ORGANISM PART": "myometrium"}}, {"GSM1152663": {"ORGANISM PART": "myometrium"}}, {"GSM1152663": {"ORGANISM PART": "myometrium"}}, {"GSM1152663": {"ORGANISM PART": "myometrium"}}, {"GSM1152655": {"ORGANISM PART": "Fibroid"}}, {"GSM1152655": {"ORGANISM PART": "Fibroid"}}, {"GSM1152655": {"ORGANISM PART": "Fibroid"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}, {"GSM1152652": {"ORGANISM PART": "endometrium"}}], "pop_total": 0, "platform": 4, "summary_wrapped": "Uterine NK cells (uNK) play a role in the regulation of placentation but their functions in non-pregnant endometrium are not understood....", "pubmed_id": 23913972, "geo_gse_id": "E-GEOD-47577", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 39, "tags": ["artery", "cell", "endometrium", "spiral"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-47577_A-AFFY-44", "slug": "regulation-of-endometrial-bleeding-by-unk-cells", "geo_gds_id": "", "name": "Regulation of endometrial bleeding by uNK cells", "created": "Jul.12, 2014", "summary": "Uterine NK cells (uNK) play a role in the regulation of placentation but their functions in non-pregnant endometrium are not understood.  We have previously reported suppression of endometrial bleeding and alteration of spiral artery morphology in women exposed to asoprisnil, a progesterone receptor modulator (PRM).  We now compare global endometrial gene expression in asoprisnil-treated versus control women and demonstrate a statistically significant reduction of genes in the IL-15 pathway, known to play a key role in uNK development and function. Suppression of IL-15 by asoprisnil was also observed at mRNA level (p<0.05), and immunostaining for NK cell marker CD56 revealed a striking reduction of uNK in asoprisnil-treated endometrium (p<0.001). IL-15 levels in normal endometrium are progesterone-responsive. Progesterone receptor (PR) positive stromal cells transcribe both IL-15 and IL-15RA. Thus, the response of stromal cells to progesterone will be to increase IL-15 trans-presentation to uNK, supporting their expansion and differentiation. In asoprisnil-treated endometrium, there is a marked down-regulation of stromal PR expression and virtual absence of uNK.  These novel findings indicate that the IL-15 pathway provides a missing link in the complex interplay between endometrial stromal cells, uNK and spiral arteries affecting physiological and pathological endometrial bleeding. 39 Samples", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-47577", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-47577/samples/"}