{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 1642, "factors": [{"GSE4698GSM106185": {}}, {"GSE4698GSM106168": {}}, {"GSE4698GSM106207": {}}, {"GSE4698GSM106200": {}}, {"GSE4698GSM106217": {}}, {"GSE4698GSM106189": {}}, {"GSE4698GSM106178": {}}, {"GSE4698GSM106195": {}}, {"GSE4698GSM106209": {}}, {"GSE4698GSM106213": {}}, {"GSE4698GSM106222": {}}, {"GSE4698GSM106221": {}}, {"GSE4698GSM106179": {}}, {"GSE4698GSM106208": {}}, {"GSE4698GSM106177": {}}, {"GSE4698GSM106212": {}}, {"GSE4698GSM106206": {}}, {"GSE4698GSM106198": {}}, {"GSE4698GSM106193": {}}, {"GSE4698GSM106171": {}}, {"GSE4698GSM106199": {}}, {"GSE4698GSM106205": {}}, {"GSE4698GSM106183": {}}, {"GSE4698GSM106187": {}}, {"GSE4698GSM106184": {}}, {"GSE4698GSM106225": {}}, {"GSE4698GSM106173": {}}, {"GSE4698GSM106214": {}}, {"GSE4698GSM106219": {}}, {"GSE4698GSM106186": {}}, {"GSE4698GSM106191": {}}, {"GSE4698GSM106167": {}}, {"GSE4698GSM106204": {}}, {"GSE4698GSM106182": {}}, {"GSE4698GSM106188": {}}, {"GSE4698GSM106180": {}}, {"GSE4698GSM106216": {}}, {"GSE4698GSM106218": {}}, {"GSE4698GSM106202": {}}, {"GSE4698GSM106210": {}}, {"GSE4698GSM106215": {}}, {"GSE4698GSM106175": {}}, {"GSE4698GSM106201": {}}, {"GSE4698GSM106192": {}}, {"GSE4698GSM106226": {}}, {"GSE4698GSM106169": {}}, {"GSE4698GSM106211": {}}, {"GSE4698GSM106176": {}}, {"GSE4698GSM106197": {}}, {"GSE4698GSM106196": {}}, {"GSE4698GSM106223": {}}, {"GSE4698GSM106224": {}}, {"GSE4698GSM106194": {}}, {"GSE4698GSM106181": {}}, {"GSE4698GSM106172": {}}, {"GSE4698GSM106174": {}}, {"GSE4698GSM106190": {}}, {"GSE4698GSM106170": {}}, {"GSE4698GSM106220": {}}, {"GSE4698GSM106203": {}}], "ownerprofile_id": "arrayexpress_sid", "platform": 3, "summary_wrapped": "Purpose: In childhood acute lymphoblastic leukemia (ALL), approximately 25% of patients suffer from relapse. In recurrent disease,...", "pubmed_id": 16899601, "geo_gse_id": "E-GEOD-4698", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 60, "tags": ["acute lymphoblastic leukemia", "cell", "disease", "face", "leukemia", "lymphoblastic leukemia"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-human-all-samples-from", "geo_id_plat": "E-GEOD-4698_A-AFFY-33", "name": "Transcription profiling of human ALL samples from very early relapsed childhood patients", "created": "Jun.19, 2014", "summary": "Purpose: In childhood acute lymphoblastic leukemia (ALL), approximately 25% of patients suffer from relapse. In recurrent disease, despite intensified therapy, overall cure rates of 40% remain unsatisfactory and survival rates are particularly poor in certain subgroups. The probability of long-term survival after relapse is predicted from well-established prognostic factors, i. e. time and site of relapse, immunophenotype and minimal residual disease. However, the underlying biological determinants of these prognostic factors remain poorly understood. Results: We show here that patients with very early relapse of ALL are characterized by a distinctive gene expression pattern. We identified a set of 83 genes differentially expressed in very early relapsed ALL compared to late relapsed disease. The vast majority of genes was up-regulated and many were late cell cycle genes with a function in mitosis. In addition, samples from patients with very early relapse showed a significant increase in the percentage of S and G/2M phase cells and this correlated well with the expression level of cell cycle genes. Conclusions: Very early relapse of ALL is characterized by an increased proliferative capacity of leukemic blasts and up-regulated mitotic genes. The latter suggests that novel drugs, targeting late cell cycle proteins, might be beneficial for these patients that typically face a dismal prognosis. Experiment Overall Design: We performed gene expression profiling on 60 prospectively collected samples of children with first relapse of acute lymphoblastic leukemia enrolled on the relapse trial ALL-REZ BFM 2002 of the Berlin-Frankfurt-Muenster study group.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-4698", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-4698/samples/"}