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Home › Dataset Library › 27-Hydroxycholesterol links cholesterol and breast cancer pathophysiology.

Dataset: 27-Hydroxycholesterol links cholesterol and breast cancer pathophysiology.

The cholesterol metabolite and SERM, 27HC, is the signaling molecule that links cholesterol to breast cancer pathophysiology...

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The cholesterol metabolite and SERM, 27HC, is the signaling molecule that links cholesterol to breast cancer pathophysiology Hypercholesterolemia is a risk factor for breast cancer, and patients taking statins demonstrate lower breast cancer incidence and decreased breast cancer recurrence, data that highlights the potential importance of the recent finding that 27-Hydroxycholesterol (27HC), a primary metabolite of cholesterol, acts as a selective estrogen receptor modulator (SERM). The goal of this study was to evaluate the impact of 27HC on breast cancer pathophysiology. Elevation of 27HC in murine models increased tumor growth in an estrogen receptor dependent manner. Importantly, a high cholesterol diet decreased the time to tumor onset and increased tumor growth, and this response required presence of CYP27A1. Within human breast cancer samples, CYP27A1 expression increasesd with grade, in addition to being highly expressed in tumor associated macrophages. Finally 27HC increases metastasis to the lung. The findings herein strongly support a role for 27HC in breast cancer pathophysiology, providing support for the exploration of potential chemopreventative benefits of lower cholesterol diets, and pharmacological inhibitors of HMG-CoA reductase or CYP27A1. MCF-7 cells were treated as indicated in the presence of E2 or vehicle; RNA was isolated and used for preparation of label for 3' expression analysis.

Species:
human

Samples:
12

Source:
E-GEOD-46924

Updated:
Dec.12, 2014

Registered:
Jul.12, 2014


Factors: (via ArrayExpress)
Sample BATCH TREATED WITH
GSM1141246 3 1 nM final conc. vehicle (ethanol) + 1 uM vehicle (ethanol) for 24hr
GSM1141245 2 1 nM final conc. vehicle (ethanol) + 1 uM vehicle (ethanol) for 24hr
GSM1141244 1 1 nM final conc. vehicle (ethanol) + 1 uM vehicle (ethanol) for 24hr
GSM1141243 3 1 nM final conc. E2 + 1 uM vehicle (ethanol) for 24hr
GSM1141242 2 1 nM final conc. E2 + 1 uM vehicle (ethanol) for 24hr
GSM114124 1 1 nM final conc. E2 + 1 uM vehicle (ethanol) for 24hr
GSM1141240 3 1 nM final conc. vehicle (ethanol) + 1 uM 27-Hydroxycholesterol (27HC) for 24hr
GSM1141239 2 1 nM final conc. vehicle (ethanol) + 1 uM 27-Hydroxycholesterol (27HC) for 24hr
GSM1141238 1 1 nM final conc. vehicle (ethanol) + 1 uM 27-Hydroxycholesterol (27HC) for 24hr
GSM1141237 3 1 nM final conc. E2 + 1 uM 27-Hydroxycholesterol (27HC) for 24hr
GSM1141236 2 1 nM final conc. E2 + 1 uM 27-Hydroxycholesterol (27HC) for 24hr
GSM1141235 1 1 nM final conc. E2 + 1 uM 27-Hydroxycholesterol (27HC) for 24hr

Tags

  • breast
  • breast cancer
  • cancer
  • estrogen
  • hypercholesterolemia
  • lung

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