ArrayExpress Uploaderarrayexpress_sidhumanMDCHD1MDCHD11MDCHD19MDCHD5MDCHD6monocyteHD1monocyteHD5monocyteHD6monocyteHD11monocyteHD191001603To directly compare the SLE monocyte transcriptional program with that of blood mDC precursors, we purified lineage HLA-DRhighCD11chigh...24829414E-GEOD-46913/profile/8773/arrayexpressuploader010monocyteJan.28, 2015Falsetranscripts-differentially-expressed-in-healthy-blE-GEOD-46913_A-AFFY-33Transcripts differentially expressed in healthy blood mDCs compared to healthy monocytesJan.28, 2015To directly compare the SLE monocyte transcriptional program with that of blood mDC precursors, we purified lineage HLA-DRhighCD11chigh mDCs and CD14+ monocytes from the blood of five healthy donors. Their gene expression profiles were then compared to those of blood SLE monocytes. An unsupervised clustering analysis of transcripts present in >20% of the samples classified healthy monocytes, SLE monocytes and healthy mDCs into three well defined groups. A supervised analysis was then performed to find genes: 1) differentially expressed in healthy mDCs compared to monocytes; 2) shared by healthy blood mDCs and SLE blood monocytes. To directly compare the SLE monocyte transcriptional program with that of blood mDC precursors, we purified lineage HLA-DRhighCD11chigh mDCs and CD14+ monocytes from the blood of five healthy donors. Their gene expression profiles were then compared to those of blood SLE monocytes. An unsupervised clustering analysis of transcripts present in >20% of the samples classified healthy monocytes, SLE monocytes and healthy mDCs into three well defined groups. A supervised analysis was then performed to find genes: 1) differentially expressed in healthy mDCs compared to monocytes; 2) shared by healthy blood mDCs and SLE blood monocytes.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46913http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46913/samples/