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<biogps><data><item key="owner">ArrayExpress Uploader</item><item key="ownerprofile_id">arrayexpress_sid</item><item key="species">mouse</item><item key="factors"><item><item key="GSM1139004"><item key="SARCOMA/TUMOR">pleomorphic RMS (pRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139004"><item key="SARCOMA/TUMOR">pleomorphic RMS (pRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139004"><item key="SARCOMA/TUMOR">pleomorphic RMS (pRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139004"><item key="SARCOMA/TUMOR">pleomorphic RMS (pRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139004"><item key="SARCOMA/TUMOR">pleomorphic RMS (pRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139004"><item key="SARCOMA/TUMOR">pleomorphic RMS (pRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139010"><item key="SARCOMA/TUMOR">embryonal RMS (eRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139010"><item key="SARCOMA/TUMOR">embryonal RMS (eRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139010"><item key="SARCOMA/TUMOR">embryonal RMS (eRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139010"><item key="SARCOMA/TUMOR">embryonal RMS (eRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139010"><item key="SARCOMA/TUMOR">embryonal RMS (eRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139010"><item key="SARCOMA/TUMOR">embryonal RMS (eRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139010"><item key="SARCOMA/TUMOR">embryonal RMS (eRMS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139017"><item key="SARCOMA/TUMOR">undifferentiated pleomorphic sarcoma (UPS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139017"><item key="SARCOMA/TUMOR">undifferentiated pleomorphic sarcoma (UPS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139017"><item key="SARCOMA/TUMOR">undifferentiated pleomorphic sarcoma (UPS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139017"><item key="SARCOMA/TUMOR">undifferentiated pleomorphic sarcoma (UPS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139017"><item key="SARCOMA/TUMOR">undifferentiated pleomorphic sarcoma (UPS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139017"><item key="SARCOMA/TUMOR">undifferentiated pleomorphic sarcoma (UPS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139017"><item key="SARCOMA/TUMOR">undifferentiated pleomorphic sarcoma (UPS)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in Pax7+ cells</item><item key="SARCOMA DERIVED FROM">Pax7+ cells</item></item></item><item><item key="GSM1139024"><item key="SARCOMA/TUMOR">MyoD-derived sarcoma (MDKP)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in MyoD+ cells</item><item key="SARCOMA DERIVED FROM">MyoD+ cells</item></item></item><item><item key="GSM1139024"><item key="SARCOMA/TUMOR">MyoD-derived sarcoma (MDKP)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in MyoD+ cells</item><item key="SARCOMA DERIVED FROM">MyoD+ cells</item></item></item><item><item key="GSM1139024"><item key="SARCOMA/TUMOR">MyoD-derived sarcoma (MDKP)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in MyoD+ cells</item><item key="SARCOMA DERIVED FROM">MyoD+ cells</item></item></item><item><item key="GSM1139024"><item key="SARCOMA/TUMOR">MyoD-derived sarcoma (MDKP)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in MyoD+ cells</item><item key="SARCOMA DERIVED FROM">MyoD+ cells</item></item></item><item><item key="GSM1139024"><item key="SARCOMA/TUMOR">MyoD-derived sarcoma (MDKP)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in MyoD+ cells</item><item key="SARCOMA DERIVED FROM">MyoD+ cells</item></item></item><item><item key="GSM1139024"><item key="SARCOMA/TUMOR">MyoD-derived sarcoma (MDKP)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in MyoD+ cells</item><item key="SARCOMA DERIVED FROM">MyoD+ cells</item></item></item><item><item key="GSM1139024"><item key="SARCOMA/TUMOR">MyoD-derived sarcoma (MDKP)</item><item key="GENOTYPE">mutant Kras and loss of both alleles of p53 in MyoD+ cells</item><item key="SARCOMA DERIVED FROM">MyoD+ cells</item></item></item></item><item key="id">8706</item><item key="pop_total">0</item><item key="platform">8</item><item key="summary_wrapped">The cell of origin for rhabdomyosarcoma (RMS) and undifferentiated pleomorphic sarcoma (UPS) remains to be determined.  We utilized two...</item><item key="geo_gse_id">E-GEOD-46836</item><item key="owner_profile">/profile/8773/arrayexpressuploader</item><item key="factor_count">3</item><item key="sample_count">27</item><item key="tags"><item>cell</item><item>liquid</item><item>muscle</item><item>rhabdomyosarcoma</item><item>sarcoma</item></item><item key="lastmodified">Dec.12, 2014</item><item key="is_default">False</item><item key="geo_gds_id"/><item key="slug">expression-data-from-murine-sarcomas</item><item key="geo_id_plat">E-GEOD-46836_A-AFFY-36</item><item key="name">Expression data from murine sarcomas</item><item key="created">Nov.24, 2014</item><item key="summary">The cell of origin for rhabdomyosarcoma (RMS) and undifferentiated pleomorphic sarcoma (UPS) remains to be determined.  We utilized two skeletal muscle specific inducible Cre mouse lines to transform both skeletal muscle stem cells and progenitors to determine which cells give rise to RMS and UPS. Both P7KP and MDKP derived mice were injected with systemic tamoxifen and mice were euthanized after tumor development.  Sections of resected tumor were placed in RNAlater and placed at -80 until RNA isolation.  RNA was isolated by grinding up tumor sections in liquid nitrogen and using the Qiagen RNEasy Micro kit.</item><item key="source">http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46836</item><item key="sample_source">http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46836/samples/</item></data></biogps>
