ArrayExpress Uploader0mouse6 monthsIQGAP2 knockoutnormal liver6 monthsIQGAP2 knockoutnormal liver6 monthsIQGAP2 knockoutnormal liver24 monthsIQGAP2 knockouthepatocellular carcinoma (HCC) tumor24 monthsIQGAP2 knockouthepatocellular carcinoma (HCC) tumor24 monthsIQGAP2 knockouthepatocellular carcinoma (HCC) tumor6 monthswild-typenormal liver6 monthswild-typenormal liver6 monthswild-typenormal liver24 monthswild-typenormal liver24 monthswild-typenormal liver24 monthswild-typenormal liver7280arrayexpress_sid6Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma...E-GEOD-46646/profile/8773/arrayexpressuploader312bodycarcinomagenomehepatocellular carcinomaliverproteinDec.12, 2014Falseiqgap2-knockout-model-of-hepatocellular-carcinomaE-GEOD-46646_A-AFFY-45IQGAP2 knockout model of hepatocellular carcinomaNov.12, 2014Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma (HCC) at the age of 12 months and older (Schmidt et al., 2008). Hepatic transcript expression profiles were obtained for IQGAP2 knockout and wild-type control mice of two age groups, 6- and 24-month-old. Liver samples from 24-month-old IQGAP2 knockout mice were HCC tumors, livers from all other groups were tumor-free. Results provide insights into the potential role of IQGAP2 as a liver-specific tumor suppressor. Transcript profiles of four groups of mouse livers (N = 3 in each group) were compared using Affymetrix GeneChip® Mouse Genome 430 2.0 Array. The groups included livers from 6- and 24-month-old wild-type (WT) mice and 6- and 24-month-old (KO) Iqgap2-/- mice.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46646http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46646/samples/