{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM1133576": {"AGE": "6 months", "GENOTYPE": "IQGAP2 knockout", "ORGANISM PART": "normal liver"}}, {"GSM1133576": {"AGE": "6 months", "GENOTYPE": "IQGAP2 knockout", "ORGANISM PART": "normal liver"}}, {"GSM1133576": {"AGE": "6 months", "GENOTYPE": "IQGAP2 knockout", "ORGANISM PART": "normal liver"}}, {"GSM1133579": {"AGE": "24 months", "GENOTYPE": "IQGAP2 knockout", "ORGANISM PART": "hepatocellular carcinoma (HCC) tumor"}}, {"GSM1133579": {"AGE": "24 months", "GENOTYPE": "IQGAP2 knockout", "ORGANISM PART": "hepatocellular carcinoma (HCC) tumor"}}, {"GSM1133579": {"AGE": "24 months", "GENOTYPE": "IQGAP2 knockout", "ORGANISM PART": "hepatocellular carcinoma (HCC) tumor"}}, {"GSM1133582": {"AGE": "6 months", "GENOTYPE": "wild-type", "ORGANISM PART": "normal liver"}}, {"GSM1133582": {"AGE": "6 months", "GENOTYPE": "wild-type", "ORGANISM PART": "normal liver"}}, {"GSM1133582": {"AGE": "6 months", "GENOTYPE": "wild-type", "ORGANISM PART": "normal liver"}}, {"GSM1133585": {"AGE": "24 months", "GENOTYPE": "wild-type", "ORGANISM PART": "normal liver"}}, {"GSM1133585": {"AGE": "24 months", "GENOTYPE": "wild-type", "ORGANISM PART": "normal liver"}}, {"GSM1133585": {"AGE": "24 months", "GENOTYPE": "wild-type", "ORGANISM PART": "normal liver"}}], "id": 7280, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma...", "geo_gse_id": "E-GEOD-46646", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 12, "tags": ["body", "carcinoma", "genome", "hepatocellular carcinoma", "liver", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "iqgap2-knockout-model-of-hepatocellular-carcinoma", "geo_id_plat": "E-GEOD-46646_A-AFFY-45", "name": "IQGAP2 knockout model of hepatocellular carcinoma", "created": "Nov.12, 2014", "summary": "Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma (HCC) at the age of 12 months and older (Schmidt et al., 2008). Hepatic transcript expression profiles were obtained for IQGAP2 knockout and wild-type control mice of two age groups, 6- and 24-month-old. Liver samples from 24-month-old IQGAP2 knockout mice were HCC tumors, livers from all other groups were tumor-free. Results provide insights into the potential role of IQGAP2 as a liver-specific tumor suppressor. Transcript profiles of four groups of mouse livers (N = 3 in each group) were compared using Affymetrix GeneChip\u00ae Mouse Genome 430 2.0 Array. The groups included livers from 6- and 24-month-old wild-type (WT) mice and 6- and 24-month-old (KO) Iqgap2-/- mice.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46646", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-46646/samples/"}